Effect of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on diabetes remission in adults with obesity and type 2 diabetes: a randomized controlled trial
Abstract Background This study aimed to explore the effects of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on weight loss and diabetes remission in adults with obesity and newly diagnosed prediabetes/type 2 diabetes (T2D). Methods Participants with obes...
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2025-05-01
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| Online Access: | https://doi.org/10.1186/s12916-025-04072-4 |
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| author | Shi Zhang Yi Wang Xincheng Wang Mingxin Leng Renjiao Liu Zhouhuiling Li Jing Li Jixuan Xiao Dangmin Hou Xinying Gao Chunjun Li |
| author_facet | Shi Zhang Yi Wang Xincheng Wang Mingxin Leng Renjiao Liu Zhouhuiling Li Jing Li Jixuan Xiao Dangmin Hou Xinying Gao Chunjun Li |
| author_sort | Shi Zhang |
| collection | DOAJ |
| description | Abstract Background This study aimed to explore the effects of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on weight loss and diabetes remission in adults with obesity and newly diagnosed prediabetes/type 2 diabetes (T2D). Methods Participants with obesity and newly diagnosed prediabetes or T2D (n = 61) were randomly allocated to standard treatment group (conventional medication and lifestyle guidance for 12 months) and intensive treatment group (in addition to conventional medication, a high protein diet and moderate exercise were given for 12 months). Results By month 12, 60 (98.4%) participants completed the 12-month follow-up visit. In the intensive treatment group, 73.33% patients in the prediabetes subgroup returned to normoglycemia and the diabetes remission rate was 86.67% in the diabetes subgroup, which were much higher than the remission rate of prediabetes subgroup (7.69%) and diabetes subgroup (16.67%) in the standard treatment group (P < 0.001). The mean weight change was − 19.29 kg (95% CI, − 22.95 to − 15.63) in the intensive treatment group and − 1.52 kg (95% CI, − 5.12 to 2.07) in the standard treatment group from baseline after intervention. The weight change between the two groups was significantly different (net difference, − 17.77 kg; 95% CI, − 22.90 to − 12.64; P < 0.001). Percent of body fat, visceral fat area, and hepatic controlled attenuation parameter value reduced significantly in the intensive treatment group compared to the standard treatment group (P < 0.001). Conclusions Hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise could lead to a considerable proportion of patients with diabetes achieving diabetes remission. Trial registration chictr.org.cn ChiCTR2100044305. |
| format | Article |
| id | doaj-art-758da84c932d4042b3b3d1bc7bbdcd85 |
| institution | Kabale University |
| issn | 1741-7015 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj-art-758da84c932d4042b3b3d1bc7bbdcd852025-08-20T03:53:12ZengBMCBMC Medicine1741-70152025-05-0123111410.1186/s12916-025-04072-4Effect of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on diabetes remission in adults with obesity and type 2 diabetes: a randomized controlled trialShi Zhang0Yi Wang1Xincheng Wang2Mingxin Leng3Renjiao Liu4Zhouhuiling Li5Jing Li6Jixuan Xiao7Dangmin Hou8Xinying Gao9Chunjun Li10Department of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai UniversityDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai UniversityDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai UniversityDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai UniversityDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai UniversityDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai UniversityDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai UniversityDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai UniversityDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai UniversityDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai UniversityDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai UniversityAbstract Background This study aimed to explore the effects of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on weight loss and diabetes remission in adults with obesity and newly diagnosed prediabetes/type 2 diabetes (T2D). Methods Participants with obesity and newly diagnosed prediabetes or T2D (n = 61) were randomly allocated to standard treatment group (conventional medication and lifestyle guidance for 12 months) and intensive treatment group (in addition to conventional medication, a high protein diet and moderate exercise were given for 12 months). Results By month 12, 60 (98.4%) participants completed the 12-month follow-up visit. In the intensive treatment group, 73.33% patients in the prediabetes subgroup returned to normoglycemia and the diabetes remission rate was 86.67% in the diabetes subgroup, which were much higher than the remission rate of prediabetes subgroup (7.69%) and diabetes subgroup (16.67%) in the standard treatment group (P < 0.001). The mean weight change was − 19.29 kg (95% CI, − 22.95 to − 15.63) in the intensive treatment group and − 1.52 kg (95% CI, − 5.12 to 2.07) in the standard treatment group from baseline after intervention. The weight change between the two groups was significantly different (net difference, − 17.77 kg; 95% CI, − 22.90 to − 12.64; P < 0.001). Percent of body fat, visceral fat area, and hepatic controlled attenuation parameter value reduced significantly in the intensive treatment group compared to the standard treatment group (P < 0.001). Conclusions Hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise could lead to a considerable proportion of patients with diabetes achieving diabetes remission. Trial registration chictr.org.cn ChiCTR2100044305.https://doi.org/10.1186/s12916-025-04072-4ObesityType 2 diabetesRemissionHypoglycemic agentsWeight loss effectHigh protein diet |
| spellingShingle | Shi Zhang Yi Wang Xincheng Wang Mingxin Leng Renjiao Liu Zhouhuiling Li Jing Li Jixuan Xiao Dangmin Hou Xinying Gao Chunjun Li Effect of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on diabetes remission in adults with obesity and type 2 diabetes: a randomized controlled trial BMC Medicine Obesity Type 2 diabetes Remission Hypoglycemic agents Weight loss effect High protein diet |
| title | Effect of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on diabetes remission in adults with obesity and type 2 diabetes: a randomized controlled trial |
| title_full | Effect of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on diabetes remission in adults with obesity and type 2 diabetes: a randomized controlled trial |
| title_fullStr | Effect of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on diabetes remission in adults with obesity and type 2 diabetes: a randomized controlled trial |
| title_full_unstemmed | Effect of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on diabetes remission in adults with obesity and type 2 diabetes: a randomized controlled trial |
| title_short | Effect of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on diabetes remission in adults with obesity and type 2 diabetes: a randomized controlled trial |
| title_sort | effect of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on diabetes remission in adults with obesity and type 2 diabetes a randomized controlled trial |
| topic | Obesity Type 2 diabetes Remission Hypoglycemic agents Weight loss effect High protein diet |
| url | https://doi.org/10.1186/s12916-025-04072-4 |
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