Lower total cholesterol and HDL-C levels are associated with increased risk of Behçet’s disease in a prospective nationwide Korean study
Abstract This study explores the relationship between Behçet’s disease (BD) and serum lipid levels, focusing on a large cohort to understand the correlation between lipid profile variations and BD. Utilizing data from the Korean National Healthcare Insurance Service, it encompasses 9,914,049 individ...
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Nature Portfolio
2025-05-01
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| Online Access: | https://doi.org/10.1038/s41598-025-99179-2 |
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| author | Hyun Jee Kim Yeong Ho Kim Hwa Jung Yook Hyun Ju Oh Kyung Hyun Min Kyung Do Han Yong Gyu Park Young Bok Lee Ji Hyun Lee |
| author_facet | Hyun Jee Kim Yeong Ho Kim Hwa Jung Yook Hyun Ju Oh Kyung Hyun Min Kyung Do Han Yong Gyu Park Young Bok Lee Ji Hyun Lee |
| author_sort | Hyun Jee Kim |
| collection | DOAJ |
| description | Abstract This study explores the relationship between Behçet’s disease (BD) and serum lipid levels, focusing on a large cohort to understand the correlation between lipid profile variations and BD. Utilizing data from the Korean National Healthcare Insurance Service, it encompasses 9,914,049 individuals who participated in health screenings in 2009. The research identifies patients diagnosed with BD during a follow-up period and analyzes their lipid profiles, categorized into quartiles of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). The study calculates adjusted hazard ratios (aHR) considering age, gender, smoking history, alcohol consumption, exercise habits, income, body mass index, hypertension, and diabetes, to evaluate the impact of lipid concentrations on BD development. Results show a significant increase in BD incidence among those with lower TC and HDL-C levels (aHR for lowest vs. highest TC quartile: 1.57, 95% CI 1.40–1.76, p < 0.0001; aHR for lowest vs. highest HDL-C quartile: 1.66, 95% CI 1.48–1.86, p < 0.0001), while LDL-C and TG levels did not exhibit a statistically significant association with BD risk. Additionally, the risk of BD does not escalate in the low HDL group using lipid-lowering agents (aHR: 1.33, 95% CI 0.93–1.90, p = 0.8496). The study concludes that lower TC and HDL-C levels are associated with an increased risk of developing BD. |
| format | Article |
| id | doaj-art-758cb1dc146c491db0a2bdfecd78905a |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-758cb1dc146c491db0a2bdfecd78905a2025-08-20T02:10:56ZengNature PortfolioScientific Reports2045-23222025-05-011511910.1038/s41598-025-99179-2Lower total cholesterol and HDL-C levels are associated with increased risk of Behçet’s disease in a prospective nationwide Korean studyHyun Jee Kim0Yeong Ho Kim1Hwa Jung Yook2Hyun Ju Oh3Kyung Hyun Min4Kyung Do Han5Yong Gyu Park6Young Bok Lee7Ji Hyun Lee8Department of Dermatology, International St. Mary’s Hospital, College of Medicine, Catholic Kwandong UniversityDepartment of Dermatology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Dermatology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Dermatology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Dermatology, College of Medicine, Uijeongbu St. Mary’s Hospital, The Catholic University of KoreaDepartment of Statistics and Actuarial Science, Soongsil UniversityDepartment of Biostatistics, College of Medicine, The Catholic University of KoreaDepartment of Dermatology, College of Medicine, Uijeongbu St. Mary’s Hospital, The Catholic University of KoreaDepartment of Dermatology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaAbstract This study explores the relationship between Behçet’s disease (BD) and serum lipid levels, focusing on a large cohort to understand the correlation between lipid profile variations and BD. Utilizing data from the Korean National Healthcare Insurance Service, it encompasses 9,914,049 individuals who participated in health screenings in 2009. The research identifies patients diagnosed with BD during a follow-up period and analyzes their lipid profiles, categorized into quartiles of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). The study calculates adjusted hazard ratios (aHR) considering age, gender, smoking history, alcohol consumption, exercise habits, income, body mass index, hypertension, and diabetes, to evaluate the impact of lipid concentrations on BD development. Results show a significant increase in BD incidence among those with lower TC and HDL-C levels (aHR for lowest vs. highest TC quartile: 1.57, 95% CI 1.40–1.76, p < 0.0001; aHR for lowest vs. highest HDL-C quartile: 1.66, 95% CI 1.48–1.86, p < 0.0001), while LDL-C and TG levels did not exhibit a statistically significant association with BD risk. Additionally, the risk of BD does not escalate in the low HDL group using lipid-lowering agents (aHR: 1.33, 95% CI 0.93–1.90, p = 0.8496). The study concludes that lower TC and HDL-C levels are associated with an increased risk of developing BD.https://doi.org/10.1038/s41598-025-99179-2Behçet syndromeDyslipidemiasCholesterol, HDLCohort studiesRisk factors |
| spellingShingle | Hyun Jee Kim Yeong Ho Kim Hwa Jung Yook Hyun Ju Oh Kyung Hyun Min Kyung Do Han Yong Gyu Park Young Bok Lee Ji Hyun Lee Lower total cholesterol and HDL-C levels are associated with increased risk of Behçet’s disease in a prospective nationwide Korean study Scientific Reports Behçet syndrome Dyslipidemias Cholesterol, HDL Cohort studies Risk factors |
| title | Lower total cholesterol and HDL-C levels are associated with increased risk of Behçet’s disease in a prospective nationwide Korean study |
| title_full | Lower total cholesterol and HDL-C levels are associated with increased risk of Behçet’s disease in a prospective nationwide Korean study |
| title_fullStr | Lower total cholesterol and HDL-C levels are associated with increased risk of Behçet’s disease in a prospective nationwide Korean study |
| title_full_unstemmed | Lower total cholesterol and HDL-C levels are associated with increased risk of Behçet’s disease in a prospective nationwide Korean study |
| title_short | Lower total cholesterol and HDL-C levels are associated with increased risk of Behçet’s disease in a prospective nationwide Korean study |
| title_sort | lower total cholesterol and hdl c levels are associated with increased risk of behcet s disease in a prospective nationwide korean study |
| topic | Behçet syndrome Dyslipidemias Cholesterol, HDL Cohort studies Risk factors |
| url | https://doi.org/10.1038/s41598-025-99179-2 |
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