Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6

Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6

Abstract Natural killer (NK) cell development and functionality rely on precise regulation by specific transcription factors (TFs). Our study demonstrates that the nuclear orphan receptor NR2F6 represses the expression of the activating receptor NKp46, an established key player in NK cell-mediated c...

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Bibliographic Details
Main Authors: Johannes Woelk, Florian Hornsteiner, Stephanie Aschauer-Wallner, Patrizia Stoitzner, Gottfried Baier, Natascha Hermann-Kleiter
Format: Article
Language:English
Published: Nature Publishing Group 2025-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07407-4
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