Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han Population
Aims. Protein kinase-like endoplasmic reticulum kinase (PERK)/eukaryotic translation initiation factor 2 alpha (eIF2α) pathway mutations lead to failure of β-cell function. The aim of this article was to assess the association between eIF2α and the risk of glucose metabolism abnormalities. Methods....
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/6590532 |
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| author | Nan Gu Xiaowei Ma Jianwei Zhang Mengmeng Jin Nan Feng Ruifen Deng Ge Bai Hong Zhang Xiaohui Guo |
| author_facet | Nan Gu Xiaowei Ma Jianwei Zhang Mengmeng Jin Nan Feng Ruifen Deng Ge Bai Hong Zhang Xiaohui Guo |
| author_sort | Nan Gu |
| collection | DOAJ |
| description | Aims. Protein kinase-like endoplasmic reticulum kinase (PERK)/eukaryotic translation initiation factor 2 alpha (eIF2α) pathway mutations lead to failure of β-cell function. The aim of this article was to assess the association between eIF2α and the risk of glucose metabolism abnormalities. Methods. Two eIF2α SNPs (rs9840992 T>C and rs13072593 A>G) were selected based on CHB data from HapMap, and 1466 unrelated nondiabetes individuals were genotyped. All subjects were examined by the 75 g oral glucose tolerance test, and 733 participated in a subsequent insulin release test. Various indicators of insulin resistance and islet β-cell function were examined. Results. There were no significant differences in genotype distribution and allele frequency between the prediabetes and controls. CC genotype carriers at rs9840992 showed higher insulin levels at 120 min after a 75 g glucose load than noncarriers. Also, CC homozygotes had higher ΔI30/ΔG30 and ΔI120/ΔG120 than noncarriers, even after adjusting for insulin resistance. CC homozygotes had greater AUCi values than noncarriers. Subjects aged ≥ 65 yrs, those with a BMI ≥ 24 kg/m2 and those carrying the rs9840992 risk allele, had a 2.5-fold higher risk of glucose abnormalities than subjects who had none of these risk factors. Conclusion. The eIF2α polymorphism is associated with islet β-cell function in a Chinese population. |
| format | Article |
| id | doaj-art-7585b6124d584131beec6cbbb398ddfe |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-7585b6124d584131beec6cbbb398ddfe2025-08-20T02:06:57ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/65905326590532Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han PopulationNan Gu0Xiaowei Ma1Jianwei Zhang2Mengmeng Jin3Nan Feng4Ruifen Deng5Ge Bai6Hong Zhang7Xiaohui Guo8Endocrinology Department, Peking University First Hospital, Beijing, ChinaEndocrinology Department, Peking University First Hospital, Beijing, ChinaEndocrinology Department, Peking University First Hospital, Beijing, ChinaEndocrinology Department, Peking University First Hospital, Beijing, ChinaEndocrinology Department, Peking University First Hospital, Beijing, ChinaEndocrinology Department, Peking University First Hospital, Beijing, ChinaEndocrinology Department, Peking University First Hospital, Beijing, ChinaEndocrinology Department, Peking University First Hospital, Beijing, ChinaEndocrinology Department, Peking University First Hospital, Beijing, ChinaAims. Protein kinase-like endoplasmic reticulum kinase (PERK)/eukaryotic translation initiation factor 2 alpha (eIF2α) pathway mutations lead to failure of β-cell function. The aim of this article was to assess the association between eIF2α and the risk of glucose metabolism abnormalities. Methods. Two eIF2α SNPs (rs9840992 T>C and rs13072593 A>G) were selected based on CHB data from HapMap, and 1466 unrelated nondiabetes individuals were genotyped. All subjects were examined by the 75 g oral glucose tolerance test, and 733 participated in a subsequent insulin release test. Various indicators of insulin resistance and islet β-cell function were examined. Results. There were no significant differences in genotype distribution and allele frequency between the prediabetes and controls. CC genotype carriers at rs9840992 showed higher insulin levels at 120 min after a 75 g glucose load than noncarriers. Also, CC homozygotes had higher ΔI30/ΔG30 and ΔI120/ΔG120 than noncarriers, even after adjusting for insulin resistance. CC homozygotes had greater AUCi values than noncarriers. Subjects aged ≥ 65 yrs, those with a BMI ≥ 24 kg/m2 and those carrying the rs9840992 risk allele, had a 2.5-fold higher risk of glucose abnormalities than subjects who had none of these risk factors. Conclusion. The eIF2α polymorphism is associated with islet β-cell function in a Chinese population.http://dx.doi.org/10.1155/2018/6590532 |
| spellingShingle | Nan Gu Xiaowei Ma Jianwei Zhang Mengmeng Jin Nan Feng Ruifen Deng Ge Bai Hong Zhang Xiaohui Guo Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han Population International Journal of Endocrinology |
| title | Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han Population |
| title_full | Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han Population |
| title_fullStr | Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han Population |
| title_full_unstemmed | Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han Population |
| title_short | Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han Population |
| title_sort | genetic variability in eif2α gene is associated with islet β cell function in the development of diabetes in a chinese han population |
| url | http://dx.doi.org/10.1155/2018/6590532 |
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