Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han Population

Aims. Protein kinase-like endoplasmic reticulum kinase (PERK)/eukaryotic translation initiation factor 2 alpha (eIF2α) pathway mutations lead to failure of β-cell function. The aim of this article was to assess the association between eIF2α and the risk of glucose metabolism abnormalities. Methods....

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Main Authors: Nan Gu, Xiaowei Ma, Jianwei Zhang, Mengmeng Jin, Nan Feng, Ruifen Deng, Ge Bai, Hong Zhang, Xiaohui Guo
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:International Journal of Endocrinology
Online Access:http://dx.doi.org/10.1155/2018/6590532
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author Nan Gu
Xiaowei Ma
Jianwei Zhang
Mengmeng Jin
Nan Feng
Ruifen Deng
Ge Bai
Hong Zhang
Xiaohui Guo
author_facet Nan Gu
Xiaowei Ma
Jianwei Zhang
Mengmeng Jin
Nan Feng
Ruifen Deng
Ge Bai
Hong Zhang
Xiaohui Guo
author_sort Nan Gu
collection DOAJ
description Aims. Protein kinase-like endoplasmic reticulum kinase (PERK)/eukaryotic translation initiation factor 2 alpha (eIF2α) pathway mutations lead to failure of β-cell function. The aim of this article was to assess the association between eIF2α and the risk of glucose metabolism abnormalities. Methods. Two eIF2α SNPs (rs9840992 T>C and rs13072593 A>G) were selected based on CHB data from HapMap, and 1466 unrelated nondiabetes individuals were genotyped. All subjects were examined by the 75 g oral glucose tolerance test, and 733 participated in a subsequent insulin release test. Various indicators of insulin resistance and islet β-cell function were examined. Results. There were no significant differences in genotype distribution and allele frequency between the prediabetes and controls. CC genotype carriers at rs9840992 showed higher insulin levels at 120 min after a 75 g glucose load than noncarriers. Also, CC homozygotes had higher ΔI30/ΔG30 and ΔI120/ΔG120 than noncarriers, even after adjusting for insulin resistance. CC homozygotes had greater AUCi values than noncarriers. Subjects aged ≥ 65 yrs, those with a BMI ≥ 24 kg/m2 and those carrying the rs9840992 risk allele, had a 2.5-fold higher risk of glucose abnormalities than subjects who had none of these risk factors. Conclusion. The eIF2α polymorphism is associated with islet β-cell function in a Chinese population.
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spelling doaj-art-7585b6124d584131beec6cbbb398ddfe2025-08-20T02:06:57ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/65905326590532Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han PopulationNan Gu0Xiaowei Ma1Jianwei Zhang2Mengmeng Jin3Nan Feng4Ruifen Deng5Ge Bai6Hong Zhang7Xiaohui Guo8Endocrinology Department, Peking University First Hospital, Beijing, ChinaEndocrinology Department, Peking University First Hospital, Beijing, ChinaEndocrinology Department, Peking University First Hospital, Beijing, ChinaEndocrinology Department, Peking University First Hospital, Beijing, ChinaEndocrinology Department, Peking University First Hospital, Beijing, ChinaEndocrinology Department, Peking University First Hospital, Beijing, ChinaEndocrinology Department, Peking University First Hospital, Beijing, ChinaEndocrinology Department, Peking University First Hospital, Beijing, ChinaEndocrinology Department, Peking University First Hospital, Beijing, ChinaAims. Protein kinase-like endoplasmic reticulum kinase (PERK)/eukaryotic translation initiation factor 2 alpha (eIF2α) pathway mutations lead to failure of β-cell function. The aim of this article was to assess the association between eIF2α and the risk of glucose metabolism abnormalities. Methods. Two eIF2α SNPs (rs9840992 T>C and rs13072593 A>G) were selected based on CHB data from HapMap, and 1466 unrelated nondiabetes individuals were genotyped. All subjects were examined by the 75 g oral glucose tolerance test, and 733 participated in a subsequent insulin release test. Various indicators of insulin resistance and islet β-cell function were examined. Results. There were no significant differences in genotype distribution and allele frequency between the prediabetes and controls. CC genotype carriers at rs9840992 showed higher insulin levels at 120 min after a 75 g glucose load than noncarriers. Also, CC homozygotes had higher ΔI30/ΔG30 and ΔI120/ΔG120 than noncarriers, even after adjusting for insulin resistance. CC homozygotes had greater AUCi values than noncarriers. Subjects aged ≥ 65 yrs, those with a BMI ≥ 24 kg/m2 and those carrying the rs9840992 risk allele, had a 2.5-fold higher risk of glucose abnormalities than subjects who had none of these risk factors. Conclusion. The eIF2α polymorphism is associated with islet β-cell function in a Chinese population.http://dx.doi.org/10.1155/2018/6590532
spellingShingle Nan Gu
Xiaowei Ma
Jianwei Zhang
Mengmeng Jin
Nan Feng
Ruifen Deng
Ge Bai
Hong Zhang
Xiaohui Guo
Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han Population
International Journal of Endocrinology
title Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han Population
title_full Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han Population
title_fullStr Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han Population
title_full_unstemmed Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han Population
title_short Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han Population
title_sort genetic variability in eif2α gene is associated with islet β cell function in the development of diabetes in a chinese han population
url http://dx.doi.org/10.1155/2018/6590532
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