Autoimmune Hepatitis—Immunologically Triggered Liver Pathogenesis—Diagnostic and Therapeutic Strategies
Autoimmune hepatitis (AIH) is a severe liver disease that arises in genetically predisposed male and female individuals worldwide. Diagnosis of AIH is made clinically applying diagnostic scores; however, the heterotopic disease phenotype often makes a rapid determination of disease challenging. AIH...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/9437043 |
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| _version_ | 1832564758084059136 |
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| author | Elisabeth Sucher Robert Sucher Tanja Gradistanac Gerald Brandacher Stefan Schneeberger Thomas Berg |
| author_facet | Elisabeth Sucher Robert Sucher Tanja Gradistanac Gerald Brandacher Stefan Schneeberger Thomas Berg |
| author_sort | Elisabeth Sucher |
| collection | DOAJ |
| description | Autoimmune hepatitis (AIH) is a severe liver disease that arises in genetically predisposed male and female individuals worldwide. Diagnosis of AIH is made clinically applying diagnostic scores; however, the heterotopic disease phenotype often makes a rapid determination of disease challenging. AIH responds favorably to steroids and pharmacologic immunosuppression, and liver transplantation is only necessary in cases with acute liver failure or end-stage liver cirrhosis. Recurrence or development of de novo AIH after transplantation is possible, and treatment is similar to standard AIH therapy. Current experimental investigations of T cell-mediated autoimmune pathways and analysis of changes within the intestinal microbiome might advance our knowledge on the pathogenesis of AIH and trigger a spark of hope for novel therapeutic strategies. |
| format | Article |
| id | doaj-art-7583b5799ec644b0ab0460f6ead5a926 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-7583b5799ec644b0ab0460f6ead5a9262025-02-03T01:10:21ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/94370439437043Autoimmune Hepatitis—Immunologically Triggered Liver Pathogenesis—Diagnostic and Therapeutic StrategiesElisabeth Sucher0Robert Sucher1Tanja Gradistanac2Gerald Brandacher3Stefan Schneeberger4Thomas Berg5Division of Hepatology, Clinic and Polyclinic for Gastroenterology, Hepatology, Infectiology, and Pneumology, University Clinic Leipzig, GermanyDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, Division of Hepatobiliary Surgery and Visceral Transplant Surgery, University Clinic Leipzig, GermanyDepartment of Pathology, University Clinic Leipzig, GermanyDepartment of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory, Johns Hopkins University, Baltimore, Maryland, USADepartment of Visceral, Transplant, and Thoracic Surgery, University Clinic Innsbruck, Tirol, AustriaDivision of Hepatology, Clinic and Polyclinic for Gastroenterology, Hepatology, Infectiology, and Pneumology, University Clinic Leipzig, GermanyAutoimmune hepatitis (AIH) is a severe liver disease that arises in genetically predisposed male and female individuals worldwide. Diagnosis of AIH is made clinically applying diagnostic scores; however, the heterotopic disease phenotype often makes a rapid determination of disease challenging. AIH responds favorably to steroids and pharmacologic immunosuppression, and liver transplantation is only necessary in cases with acute liver failure or end-stage liver cirrhosis. Recurrence or development of de novo AIH after transplantation is possible, and treatment is similar to standard AIH therapy. Current experimental investigations of T cell-mediated autoimmune pathways and analysis of changes within the intestinal microbiome might advance our knowledge on the pathogenesis of AIH and trigger a spark of hope for novel therapeutic strategies.http://dx.doi.org/10.1155/2019/9437043 |
| spellingShingle | Elisabeth Sucher Robert Sucher Tanja Gradistanac Gerald Brandacher Stefan Schneeberger Thomas Berg Autoimmune Hepatitis—Immunologically Triggered Liver Pathogenesis—Diagnostic and Therapeutic Strategies Journal of Immunology Research |
| title | Autoimmune Hepatitis—Immunologically Triggered Liver Pathogenesis—Diagnostic and Therapeutic Strategies |
| title_full | Autoimmune Hepatitis—Immunologically Triggered Liver Pathogenesis—Diagnostic and Therapeutic Strategies |
| title_fullStr | Autoimmune Hepatitis—Immunologically Triggered Liver Pathogenesis—Diagnostic and Therapeutic Strategies |
| title_full_unstemmed | Autoimmune Hepatitis—Immunologically Triggered Liver Pathogenesis—Diagnostic and Therapeutic Strategies |
| title_short | Autoimmune Hepatitis—Immunologically Triggered Liver Pathogenesis—Diagnostic and Therapeutic Strategies |
| title_sort | autoimmune hepatitis immunologically triggered liver pathogenesis diagnostic and therapeutic strategies |
| url | http://dx.doi.org/10.1155/2019/9437043 |
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