The role of astrocytes from synaptic to non-synaptic plasticity
Information storage and transfer in the brain require a high computational power. Neuronal network display various local or global mechanisms to allow information storage and transfer in the brain. From synaptic to intrinsic plasticity, the rules of input–output function modulation have been well ch...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1477985/full |
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| author | Rafael Sanz-Gálvez Rafael Sanz-Gálvez Dominic Falardeau Dominic Falardeau Arlette Kolta Arlette Kolta Arlette Kolta Yanis Inglebert Yanis Inglebert |
| author_facet | Rafael Sanz-Gálvez Rafael Sanz-Gálvez Dominic Falardeau Dominic Falardeau Arlette Kolta Arlette Kolta Arlette Kolta Yanis Inglebert Yanis Inglebert |
| author_sort | Rafael Sanz-Gálvez |
| collection | DOAJ |
| description | Information storage and transfer in the brain require a high computational power. Neuronal network display various local or global mechanisms to allow information storage and transfer in the brain. From synaptic to intrinsic plasticity, the rules of input–output function modulation have been well characterized in neurons. In the past years, astrocytes have been suggested to increase the computational power of the brain and we are only just starting to uncover their role in information processing. Astrocytes maintain a close bidirectional communication with neurons to modify neuronal network excitability, transmission, axonal conduction, and plasticity through various mechanisms including the release of gliotransmitters or local ion homeostasis. Astrocytes have been significantly studied in the context of long-term or short-term synaptic plasticity, but this is not the only mechanism involved in memory formation. Plasticity of intrinsic neuronal excitability also participates in memory storage through regulation of voltage-gated ion channels or axonal morphological changes. Yet, the contribution of astrocytes to these other forms of non-synaptic plasticity remains to be investigated. In this review, we summarized the recent advances on the role of astrocytes in different forms of plasticity and discuss new directions and ideas to be explored regarding astrocytes-neuronal communication and regulation of plasticity. |
| format | Article |
| id | doaj-art-757f56f296f94689a51b6b2b204a33d5 |
| institution | OA Journals |
| issn | 1662-5102 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-757f56f296f94689a51b6b2b204a33d52025-08-20T01:47:50ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022024-10-011810.3389/fncel.2024.14779851477985The role of astrocytes from synaptic to non-synaptic plasticityRafael Sanz-Gálvez0Rafael Sanz-Gálvez1Dominic Falardeau2Dominic Falardeau3Arlette Kolta4Arlette Kolta5Arlette Kolta6Yanis Inglebert7Yanis Inglebert8Department of Neurosciences, Université de Montréal, Montréal, QC, CanadaCentre Interdisciplinaire de Recherche sur le Cerveau et l’Apprentissage (CIRCA), Montréal, QC, CanadaDepartment of Neurosciences, Université de Montréal, Montréal, QC, CanadaCentre Interdisciplinaire de Recherche sur le Cerveau et l’Apprentissage (CIRCA), Montréal, QC, CanadaDepartment of Neurosciences, Université de Montréal, Montréal, QC, CanadaCentre Interdisciplinaire de Recherche sur le Cerveau et l’Apprentissage (CIRCA), Montréal, QC, CanadaDepartment of Stomatology, Université de Montréal, Montréal, QC, CanadaDepartment of Neurosciences, Université de Montréal, Montréal, QC, CanadaCentre Interdisciplinaire de Recherche sur le Cerveau et l’Apprentissage (CIRCA), Montréal, QC, CanadaInformation storage and transfer in the brain require a high computational power. Neuronal network display various local or global mechanisms to allow information storage and transfer in the brain. From synaptic to intrinsic plasticity, the rules of input–output function modulation have been well characterized in neurons. In the past years, astrocytes have been suggested to increase the computational power of the brain and we are only just starting to uncover their role in information processing. Astrocytes maintain a close bidirectional communication with neurons to modify neuronal network excitability, transmission, axonal conduction, and plasticity through various mechanisms including the release of gliotransmitters or local ion homeostasis. Astrocytes have been significantly studied in the context of long-term or short-term synaptic plasticity, but this is not the only mechanism involved in memory formation. Plasticity of intrinsic neuronal excitability also participates in memory storage through regulation of voltage-gated ion channels or axonal morphological changes. Yet, the contribution of astrocytes to these other forms of non-synaptic plasticity remains to be investigated. In this review, we summarized the recent advances on the role of astrocytes in different forms of plasticity and discuss new directions and ideas to be explored regarding astrocytes-neuronal communication and regulation of plasticity.https://www.frontiersin.org/articles/10.3389/fncel.2024.1477985/fullastrocytessynaptic plasticitySTDPneuronal excitabilityaxonal plasticity |
| spellingShingle | Rafael Sanz-Gálvez Rafael Sanz-Gálvez Dominic Falardeau Dominic Falardeau Arlette Kolta Arlette Kolta Arlette Kolta Yanis Inglebert Yanis Inglebert The role of astrocytes from synaptic to non-synaptic plasticity Frontiers in Cellular Neuroscience astrocytes synaptic plasticity STDP neuronal excitability axonal plasticity |
| title | The role of astrocytes from synaptic to non-synaptic plasticity |
| title_full | The role of astrocytes from synaptic to non-synaptic plasticity |
| title_fullStr | The role of astrocytes from synaptic to non-synaptic plasticity |
| title_full_unstemmed | The role of astrocytes from synaptic to non-synaptic plasticity |
| title_short | The role of astrocytes from synaptic to non-synaptic plasticity |
| title_sort | role of astrocytes from synaptic to non synaptic plasticity |
| topic | astrocytes synaptic plasticity STDP neuronal excitability axonal plasticity |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2024.1477985/full |
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