High density of TCF1+ stem-like tumor-infiltrating lymphocytes is associated with favorable disease-specific survival in NSCLC

High density of TCF1+ stem-like tumor-infiltrating lymphocytes is associated with favorable disease-specific survival in NSCLC

IntroductionTumor-infiltrating lymphocytes are both prognostic and predictive biomarkers for immunotherapy response. However, less is known about the survival benefits oftheir subpopulations.MethodsUsing machine learning models, we assessed the clinical association of the CD8+, PD1+, TCF1+ cel l sub...

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Bibliographic Details
Main Authors: Dagny Førde, Thomas Kilvær, Mona Irene Pedersen, Egil S Blix, Ilona Urbarova, Erna-Elise Paulsen, Mehrdad Rakaee, Lill-Tove Rasmussen Busund, Tom Donnem, Sigve Andersen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
NSCLC
digital pathology
CD8
PD1
TCF1
machine learning
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1504220/full
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