A comprehensive bioinformatics analysis of fatty acid metabolism-associated genes in the diagnosis and prognosis of head and neck squamous cell carcinoma
Background and purpose: One of the most prevalent types of malignancies affecting the cells in the mucosal surface of the oral cavity and pharynx regions is head and neck squamous cell carcinoma (HNSCC). This study analyzed the metabolic profile of genes involved in the metabolism of fatty acids (FA...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-05-01
|
| Series: | Research in Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/RPS.RPS_209_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850082644198424576 |
|---|---|
| author | Shirin Alsadat Hashemi Fesharaki Sara Kiani Abari Behnaz Yazdani Hadi Farajollahi Fatemeh Padidari Kalashami Anahita Zadsar Hajar Sirous |
| author_facet | Shirin Alsadat Hashemi Fesharaki Sara Kiani Abari Behnaz Yazdani Hadi Farajollahi Fatemeh Padidari Kalashami Anahita Zadsar Hajar Sirous |
| author_sort | Shirin Alsadat Hashemi Fesharaki |
| collection | DOAJ |
| description | Background and purpose:
One of the most prevalent types of malignancies affecting the cells in the mucosal surface of the oral cavity and pharynx regions is head and neck squamous cell carcinoma (HNSCC). This study analyzed the metabolic profile of genes involved in the metabolism of fatty acids (FAs) to identify biomarkers with prognostic and diagnostic potential in HNSCC.
Experimental approach:
Gene set enrichment analysis, differential gene expression, and correlation analysis methods were used to examine the enrichment and expression patterns of genes involved in the metabolism of FAs in the HNSCC tissue samples. Gene ontology and network analysis were performed to explore the molecular interactions in the metabolic pathways of FAs. The diagnostic and prognostic potentials of identified highly dysregulated genes in HNSCC were examined by ROC test and Cox-regression methods.
Findings/Results:
FA-associated metabolic pathways were significantly dysregulated in the HNSC cancer samples. For the diagnosis of HNSC cancer, CYP4B1 and FMO2 could be potential biomarkers, while for the prognosis of HNSCC survival periods, ACOX2, CYP4F12, and ELOVL6 could hold valuable biomarker potential.
Conclusion and implications:
The findings could help target the metabolism of FAs using the identified biomarkers for the design of new therapeutic opportunities for patients with HNSCC. |
| format | Article |
| id | doaj-art-7572394d080a4722a5eef3b46a53ab2e |
| institution | DOAJ |
| issn | 1735-5362 1735-9414 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Research in Pharmaceutical Sciences |
| spelling | doaj-art-7572394d080a4722a5eef3b46a53ab2e2025-08-20T02:44:28ZengWolters Kluwer Medknow PublicationsResearch in Pharmaceutical Sciences1735-53621735-94142025-05-0120335637210.4103/RPS.RPS_209_23A comprehensive bioinformatics analysis of fatty acid metabolism-associated genes in the diagnosis and prognosis of head and neck squamous cell carcinomaShirin Alsadat Hashemi FesharakiSara Kiani AbariBehnaz YazdaniHadi FarajollahiFatemeh Padidari KalashamiAnahita ZadsarHajar SirousBackground and purpose: One of the most prevalent types of malignancies affecting the cells in the mucosal surface of the oral cavity and pharynx regions is head and neck squamous cell carcinoma (HNSCC). This study analyzed the metabolic profile of genes involved in the metabolism of fatty acids (FAs) to identify biomarkers with prognostic and diagnostic potential in HNSCC. Experimental approach: Gene set enrichment analysis, differential gene expression, and correlation analysis methods were used to examine the enrichment and expression patterns of genes involved in the metabolism of FAs in the HNSCC tissue samples. Gene ontology and network analysis were performed to explore the molecular interactions in the metabolic pathways of FAs. The diagnostic and prognostic potentials of identified highly dysregulated genes in HNSCC were examined by ROC test and Cox-regression methods. Findings/Results: FA-associated metabolic pathways were significantly dysregulated in the HNSC cancer samples. For the diagnosis of HNSC cancer, CYP4B1 and FMO2 could be potential biomarkers, while for the prognosis of HNSCC survival periods, ACOX2, CYP4F12, and ELOVL6 could hold valuable biomarker potential. Conclusion and implications: The findings could help target the metabolism of FAs using the identified biomarkers for the design of new therapeutic opportunities for patients with HNSCC.https://journals.lww.com/10.4103/RPS.RPS_209_23cyp4b1diagnosiselovl6fatty acid metabolismfmo2head and neck squamous cell carcinomaprognosis |
| spellingShingle | Shirin Alsadat Hashemi Fesharaki Sara Kiani Abari Behnaz Yazdani Hadi Farajollahi Fatemeh Padidari Kalashami Anahita Zadsar Hajar Sirous A comprehensive bioinformatics analysis of fatty acid metabolism-associated genes in the diagnosis and prognosis of head and neck squamous cell carcinoma Research in Pharmaceutical Sciences cyp4b1 diagnosis elovl6 fatty acid metabolism fmo2 head and neck squamous cell carcinoma prognosis |
| title | A comprehensive bioinformatics analysis of fatty acid metabolism-associated genes in the diagnosis and prognosis of head and neck squamous cell carcinoma |
| title_full | A comprehensive bioinformatics analysis of fatty acid metabolism-associated genes in the diagnosis and prognosis of head and neck squamous cell carcinoma |
| title_fullStr | A comprehensive bioinformatics analysis of fatty acid metabolism-associated genes in the diagnosis and prognosis of head and neck squamous cell carcinoma |
| title_full_unstemmed | A comprehensive bioinformatics analysis of fatty acid metabolism-associated genes in the diagnosis and prognosis of head and neck squamous cell carcinoma |
| title_short | A comprehensive bioinformatics analysis of fatty acid metabolism-associated genes in the diagnosis and prognosis of head and neck squamous cell carcinoma |
| title_sort | comprehensive bioinformatics analysis of fatty acid metabolism associated genes in the diagnosis and prognosis of head and neck squamous cell carcinoma |
| topic | cyp4b1 diagnosis elovl6 fatty acid metabolism fmo2 head and neck squamous cell carcinoma prognosis |
| url | https://journals.lww.com/10.4103/RPS.RPS_209_23 |
| work_keys_str_mv | AT shirinalsadathashemifesharaki acomprehensivebioinformaticsanalysisoffattyacidmetabolismassociatedgenesinthediagnosisandprognosisofheadandnecksquamouscellcarcinoma AT sarakianiabari acomprehensivebioinformaticsanalysisoffattyacidmetabolismassociatedgenesinthediagnosisandprognosisofheadandnecksquamouscellcarcinoma AT behnazyazdani acomprehensivebioinformaticsanalysisoffattyacidmetabolismassociatedgenesinthediagnosisandprognosisofheadandnecksquamouscellcarcinoma AT hadifarajollahi acomprehensivebioinformaticsanalysisoffattyacidmetabolismassociatedgenesinthediagnosisandprognosisofheadandnecksquamouscellcarcinoma AT fatemehpadidarikalashami acomprehensivebioinformaticsanalysisoffattyacidmetabolismassociatedgenesinthediagnosisandprognosisofheadandnecksquamouscellcarcinoma AT anahitazadsar acomprehensivebioinformaticsanalysisoffattyacidmetabolismassociatedgenesinthediagnosisandprognosisofheadandnecksquamouscellcarcinoma AT hajarsirous acomprehensivebioinformaticsanalysisoffattyacidmetabolismassociatedgenesinthediagnosisandprognosisofheadandnecksquamouscellcarcinoma AT shirinalsadathashemifesharaki comprehensivebioinformaticsanalysisoffattyacidmetabolismassociatedgenesinthediagnosisandprognosisofheadandnecksquamouscellcarcinoma AT sarakianiabari comprehensivebioinformaticsanalysisoffattyacidmetabolismassociatedgenesinthediagnosisandprognosisofheadandnecksquamouscellcarcinoma AT behnazyazdani comprehensivebioinformaticsanalysisoffattyacidmetabolismassociatedgenesinthediagnosisandprognosisofheadandnecksquamouscellcarcinoma AT hadifarajollahi comprehensivebioinformaticsanalysisoffattyacidmetabolismassociatedgenesinthediagnosisandprognosisofheadandnecksquamouscellcarcinoma AT fatemehpadidarikalashami comprehensivebioinformaticsanalysisoffattyacidmetabolismassociatedgenesinthediagnosisandprognosisofheadandnecksquamouscellcarcinoma AT anahitazadsar comprehensivebioinformaticsanalysisoffattyacidmetabolismassociatedgenesinthediagnosisandprognosisofheadandnecksquamouscellcarcinoma AT hajarsirous comprehensivebioinformaticsanalysisoffattyacidmetabolismassociatedgenesinthediagnosisandprognosisofheadandnecksquamouscellcarcinoma |