Recent Trends in Therapeutic Approaches for Diabetes Management: A Comprehensive Update
Diabetes highlights a growing epidemic imposing serious social economic crisis to the countries around the globe. Despite scientific breakthroughs, better healthcare facilities, and improved literacy rate, the disease continues to burden several sections, especially middle and low income countries....
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/340838 |
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| author | Pragya Tiwari |
| author_facet | Pragya Tiwari |
| author_sort | Pragya Tiwari |
| collection | DOAJ |
| description | Diabetes highlights a growing epidemic imposing serious social economic crisis to the countries around the globe. Despite scientific breakthroughs, better healthcare facilities, and improved literacy rate, the disease continues to burden several sections, especially middle and low income countries. The present trends indicate the rise in premature death, posing a major threat to global development. Scientific and technological advances have witnessed the development of newer generation of drugs like sulphonylureas, biguanides, alpha glucosidase inhibitors, and thiazolidinediones with significant efficacy in reducing hyperglycemia. Recent approaches in drug discovery have contributed to the development of new class of therapeutics like Incretin mimetics, Amylin analogues, GIP analogs, Peroxisome proliferator activated receptors, and dipeptidyl peptidase-4 inhibitor as targets for potential drugs in diabetes treatment. Subsequently, the identification and clinical investigation of bioactive substances from plants have revolutionized the research on drug discovery and lead identification for diabetes management. With a focus on the emerging trends, the review article explores the current statistical prevalence of the disease, discussing the benefits and limitations of the commercially available drugs. Additionally, the critical areas in clinical diabetology are discussed, with respect to prospects of statins, nanotechnology, and stem cell technology as next generation therapeutics and why the herbal formulations are consistently popular choice for diabetes medication and management. |
| format | Article |
| id | doaj-art-756aa93cb460426c93abf08d57d0edb5 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-756aa93cb460426c93abf08d57d0edb52025-08-20T02:07:01ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/340838340838Recent Trends in Therapeutic Approaches for Diabetes Management: A Comprehensive UpdatePragya Tiwari0Department of Metabolic and Structural Biology, Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), P.O. Box CIMAP, Lucknow, Uttar Pradesh 226015, IndiaDiabetes highlights a growing epidemic imposing serious social economic crisis to the countries around the globe. Despite scientific breakthroughs, better healthcare facilities, and improved literacy rate, the disease continues to burden several sections, especially middle and low income countries. The present trends indicate the rise in premature death, posing a major threat to global development. Scientific and technological advances have witnessed the development of newer generation of drugs like sulphonylureas, biguanides, alpha glucosidase inhibitors, and thiazolidinediones with significant efficacy in reducing hyperglycemia. Recent approaches in drug discovery have contributed to the development of new class of therapeutics like Incretin mimetics, Amylin analogues, GIP analogs, Peroxisome proliferator activated receptors, and dipeptidyl peptidase-4 inhibitor as targets for potential drugs in diabetes treatment. Subsequently, the identification and clinical investigation of bioactive substances from plants have revolutionized the research on drug discovery and lead identification for diabetes management. With a focus on the emerging trends, the review article explores the current statistical prevalence of the disease, discussing the benefits and limitations of the commercially available drugs. Additionally, the critical areas in clinical diabetology are discussed, with respect to prospects of statins, nanotechnology, and stem cell technology as next generation therapeutics and why the herbal formulations are consistently popular choice for diabetes medication and management.http://dx.doi.org/10.1155/2015/340838 |
| spellingShingle | Pragya Tiwari Recent Trends in Therapeutic Approaches for Diabetes Management: A Comprehensive Update Journal of Diabetes Research |
| title | Recent Trends in Therapeutic Approaches for Diabetes Management: A Comprehensive Update |
| title_full | Recent Trends in Therapeutic Approaches for Diabetes Management: A Comprehensive Update |
| title_fullStr | Recent Trends in Therapeutic Approaches for Diabetes Management: A Comprehensive Update |
| title_full_unstemmed | Recent Trends in Therapeutic Approaches for Diabetes Management: A Comprehensive Update |
| title_short | Recent Trends in Therapeutic Approaches for Diabetes Management: A Comprehensive Update |
| title_sort | recent trends in therapeutic approaches for diabetes management a comprehensive update |
| url | http://dx.doi.org/10.1155/2015/340838 |
| work_keys_str_mv | AT pragyatiwari recenttrendsintherapeuticapproachesfordiabetesmanagementacomprehensiveupdate |