Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells
Recent studies on innate lymphoid cells (ILCs) have expanded our knowledge about the innate arm of the immune system. Helper-like ILCs share both the “innate” feature of conventional natural killer (cNK) cells and the “helper” feature of CD4+ T helper (Th) cells. With this combination, helper-like I...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/264502 |
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| _version_ | 1832556749335298048 |
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| author | Chao Zhong Jinfang Zhu |
| author_facet | Chao Zhong Jinfang Zhu |
| author_sort | Chao Zhong |
| collection | DOAJ |
| description | Recent studies on innate lymphoid cells (ILCs) have expanded our knowledge about the innate arm of the immune system. Helper-like ILCs share both the “innate” feature of conventional natural killer (cNK) cells and the “helper” feature of CD4+ T helper (Th) cells. With this combination, helper-like ILCs are capable of initiating early immune responses similar to cNK cells, but via secretion of a set of effector cytokines similar to those produced by Th cells. Although many studies have revealed the functional similarity between helper-like ILCs and Th cells, some aspects of ILCs including the development of this lineage remain elusive. It is intriguing that the majority of transcription factors involved in multiple stages of T cell development, differentiation, and function also play critical roles during ILC development. Regulators such as Id2, GATA-3, Nfil3, TOX, and TCF-1 are expressed and function at various stages of ILC development. In this review, we will summarize the expression and functions of these transcription factors shared by ILCs and Th cells. We will also propose a complex transcriptional regulatory network for the lineage commitment of ILCs. |
| format | Article |
| id | doaj-art-7568804765584ac5bc4572f4474d0795 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7568804765584ac5bc4572f4474d07952025-02-03T05:44:30ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/264502264502Transcriptional Regulatory Network for the Development of Innate Lymphoid CellsChao Zhong0Jinfang Zhu1Molecular and Cellular Immunoregulation Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USAMolecular and Cellular Immunoregulation Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USARecent studies on innate lymphoid cells (ILCs) have expanded our knowledge about the innate arm of the immune system. Helper-like ILCs share both the “innate” feature of conventional natural killer (cNK) cells and the “helper” feature of CD4+ T helper (Th) cells. With this combination, helper-like ILCs are capable of initiating early immune responses similar to cNK cells, but via secretion of a set of effector cytokines similar to those produced by Th cells. Although many studies have revealed the functional similarity between helper-like ILCs and Th cells, some aspects of ILCs including the development of this lineage remain elusive. It is intriguing that the majority of transcription factors involved in multiple stages of T cell development, differentiation, and function also play critical roles during ILC development. Regulators such as Id2, GATA-3, Nfil3, TOX, and TCF-1 are expressed and function at various stages of ILC development. In this review, we will summarize the expression and functions of these transcription factors shared by ILCs and Th cells. We will also propose a complex transcriptional regulatory network for the lineage commitment of ILCs.http://dx.doi.org/10.1155/2015/264502 |
| spellingShingle | Chao Zhong Jinfang Zhu Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells Mediators of Inflammation |
| title | Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells |
| title_full | Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells |
| title_fullStr | Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells |
| title_full_unstemmed | Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells |
| title_short | Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells |
| title_sort | transcriptional regulatory network for the development of innate lymphoid cells |
| url | http://dx.doi.org/10.1155/2015/264502 |
| work_keys_str_mv | AT chaozhong transcriptionalregulatorynetworkforthedevelopmentofinnatelymphoidcells AT jinfangzhu transcriptionalregulatorynetworkforthedevelopmentofinnatelymphoidcells |