In silico prediction of GRP78-CRIPTO binding sites to improve therapeutic targeting in glioblastoma

In silico prediction of GRP78-CRIPTO binding sites to improve therapeutic targeting in glioblastoma

Abstract Glioblastoma multiforme (GBM) is one of the most malignant tumors in central nervous system (CNS) tumors. The glucose-regulated protein 78 (GRP78) and CRIPTO (Cripto-1), a protein that belongs to the EGF-CFC (epidermal growth factor cripto-1 FRL-1 cryptic) family, are overexpressed in GBM....

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Bibliographic Details
Main Authors: Mahmoud E. Rashwan, Mahrous R. Ahmed, Abdo A. Elfiky
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
GRP78
Cripto
Glioblastoma multiforme
Computational biophysics
Protein–protein docking, molecular dynamics simulation
Online Access:https://doi.org/10.1038/s41598-025-00125-z
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