In vitro studies of human erythropoiesis using a 3D silk-based bone marrow model that generates erythroblastic islands

In vitro studies of human erythropoiesis using a 3D silk-based bone marrow model that generates erythroblastic islands

Abstract: The pursuit of ex vivo erythrocyte generation has led to the development of various culture systems that simulate the bone marrow microenvironment. However, these models often fail to fully replicate the hematopoietic niche's complex dynamics. In our research, we use a comprehensive s...

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Main Authors: Christian A. Di Buduo, Francesca Careddu, Samuele Metti, Marco Lunghi, Santo Diprima, Virginia Camilotto, Giovanna Bruni, Umberto Gianelli, Delfina Tosi, Cesare Perotti, Claudia Del Fante, Mario Cazzola, Paola Braghetta, David L. Kaplan, Giampaolo Minetti, Luca Malcovati, Alessandra Balduini
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952925001077
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