A neonate with meningitis caused by probiotic-related Clostridium butyricum
Objectives: Clostridium butyricum (C. butyricum), a normal gut bacterium in humans, is commonly used as a probiotic. We described a 26-day-old premature neonate who was diagnosed with probiotic-related C. butyricum meningitis. Design: Upon the admission, suppurative meningitis was considered based o...
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Elsevier
2025-06-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971225001237 |
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| author | Yanfang Jiang Jiaxu Yang Yong Liu Ying Liu Wenli Zhou Bin Yang Bingxue Hu Hui Wu |
| author_facet | Yanfang Jiang Jiaxu Yang Yong Liu Ying Liu Wenli Zhou Bin Yang Bingxue Hu Hui Wu |
| author_sort | Yanfang Jiang |
| collection | DOAJ |
| description | Objectives: Clostridium butyricum (C. butyricum), a normal gut bacterium in humans, is commonly used as a probiotic. We described a 26-day-old premature neonate who was diagnosed with probiotic-related C. butyricum meningitis. Design: Upon the admission, suppurative meningitis was considered based on cerebrospinal fluid (CSF) biochemical test and neuroimaging examination, and C. butyricum was subsequently identified by CSF metagenomic next-generation sequencing. Given the history of administrating living C. butyricum products before admission, probiotics-associated suppurative meningitis was considered a high possibility, leading to the confirmation of anti-infection treatment including vancomycin and meropenem. Results: Following this therapy, the infant's CSF profiles demonstrated improvement. Additionally, further phylogenetic analysis confirmed the high homologous of C. butyricum from CSF with probiotics. Conclusions: This is the first report of C. butyricum infection in neonates, highlighting the importance for prudence in administrating probiotics for neonates, particularly in high-risk groups such as preterm infants, those with central venous catheters and intestinal diseases. |
| format | Article |
| id | doaj-art-7560f9eaef9a44e0922f1074c5474e43 |
| institution | DOAJ |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj-art-7560f9eaef9a44e0922f1074c5474e432025-08-20T02:58:18ZengElsevierInternational Journal of Infectious Diseases1201-97122025-06-0115510790010.1016/j.ijid.2025.107900A neonate with meningitis caused by probiotic-related Clostridium butyricumYanfang Jiang0Jiaxu Yang1Yong Liu2Ying Liu3Wenli Zhou4Bin Yang5Bingxue Hu6Hui Wu7Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun, Jilin Province, ChinaDepartment of Neonatology, The First Hospital of Jilin University, Changchun, Jilin Province, ChinaGenetic Diagnosis Center, The First Hospital of Jilin University, Changchun, Jilin Province, ChinaDepartment of Neonatology, The First Hospital of Jilin University, Changchun, Jilin Province, ChinaDepartment of Neonatology, The First Hospital of Jilin University, Changchun, Jilin Province, ChinaCenter for Infectious Diseases, Vision Medicals Co., Ltd, Guangzhou, Guangdong Province, ChinaCenter for Infectious Diseases, Vision Medicals Co., Ltd, Guangzhou, Guangdong Province, ChinaDepartment of Neonatology, The First Hospital of Jilin University, Changchun, Jilin Province, China; Correspondence: Hui Wu, The First Hospital of Jilin University, Changchun, Jilin Province, 130021, China.Objectives: Clostridium butyricum (C. butyricum), a normal gut bacterium in humans, is commonly used as a probiotic. We described a 26-day-old premature neonate who was diagnosed with probiotic-related C. butyricum meningitis. Design: Upon the admission, suppurative meningitis was considered based on cerebrospinal fluid (CSF) biochemical test and neuroimaging examination, and C. butyricum was subsequently identified by CSF metagenomic next-generation sequencing. Given the history of administrating living C. butyricum products before admission, probiotics-associated suppurative meningitis was considered a high possibility, leading to the confirmation of anti-infection treatment including vancomycin and meropenem. Results: Following this therapy, the infant's CSF profiles demonstrated improvement. Additionally, further phylogenetic analysis confirmed the high homologous of C. butyricum from CSF with probiotics. Conclusions: This is the first report of C. butyricum infection in neonates, highlighting the importance for prudence in administrating probiotics for neonates, particularly in high-risk groups such as preterm infants, those with central venous catheters and intestinal diseases.http://www.sciencedirect.com/science/article/pii/S1201971225001237MeningitisNeonateProbioticsClostridium butyricum |
| spellingShingle | Yanfang Jiang Jiaxu Yang Yong Liu Ying Liu Wenli Zhou Bin Yang Bingxue Hu Hui Wu A neonate with meningitis caused by probiotic-related Clostridium butyricum International Journal of Infectious Diseases Meningitis Neonate Probiotics Clostridium butyricum |
| title | A neonate with meningitis caused by probiotic-related Clostridium butyricum |
| title_full | A neonate with meningitis caused by probiotic-related Clostridium butyricum |
| title_fullStr | A neonate with meningitis caused by probiotic-related Clostridium butyricum |
| title_full_unstemmed | A neonate with meningitis caused by probiotic-related Clostridium butyricum |
| title_short | A neonate with meningitis caused by probiotic-related Clostridium butyricum |
| title_sort | neonate with meningitis caused by probiotic related clostridium butyricum |
| topic | Meningitis Neonate Probiotics Clostridium butyricum |
| url | http://www.sciencedirect.com/science/article/pii/S1201971225001237 |
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