Serum Antioxidant (Vitamin E and Glutathione) in Pre-Senile Cataract Patients and healthy control in Gaza, Palestine: A Case–Control Study
Pre-senile cataract is the opacity of the crystalline lens of the eye before the age of 50 years. Recently, the incidence of early-onset cataracts has been on the rise. It is closely linked with oxidative stress and antioxidant deficiency. To identify the relationship between serum antioxidant level...
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2023-08-01
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| author | Sujod F. Aljazzar Marwan O. Jalambo Kanan M. Wahedy |
| author_facet | Sujod F. Aljazzar Marwan O. Jalambo Kanan M. Wahedy |
| author_sort | Sujod F. Aljazzar |
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| description | Pre-senile cataract is the opacity of the crystalline lens of the eye before the age of 50 years. Recently, the incidence of early-onset cataracts has been on the rise. It is closely linked with oxidative stress and antioxidant deficiency. To identify the relationship between serum antioxidant levels (vitamin E and glutathione) and the occurrence of pre-senile cataract, to measure serum vitamin E and glutathione levels in patients with pre-senile cataract and compare them with those of people without a cataract, to determine the effect of dietary habits and socioeconomic status on pre-senile cataract patients and identify the relationship between anthropometric measurements and occurrence of pre-senile cataract, a retrospective case–control study was conducted at an eye hospital in Gaza City. The study consisted of 44 cases of pre-senile cataract patients and 44 cases of region-, sex-, and age-matched controls. Data collection was performed by direct methods that included anthropometric measurement and serum vitamin E and glutathione levels and indirect methods through a structured interview questionnaire. SPSS software version 24 was used to analyze the data. Regarding serum antioxidant status, serum vitamin E and glutathione levels in pre-senile cataract patients were equal to those of healthy controls. The majority of patients were illiterate, married women. An increase in body weight and obesity had a strong association with pre-senile cataract formation. Concerning dietary factors, a high intake of fruits, meat and meat products, starchy food (grains), and healthy snacks was inversely correlated with pre-senile cataract. A direct relationship between vitamin E and glutathione was found. The study concluded that pre-senile cataract is a multifactorial disease and many risk factors (dietary factors, socio-economic factors, medical factors, and anthropometrics factors) play a role in pre-senile cataract formation. |
| format | Article |
| id | doaj-art-755bbbce50cf429da59c8c0096023da1 |
| institution | Kabale University |
| issn | 2504-3900 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Proceedings |
| spelling | doaj-art-755bbbce50cf429da59c8c0096023da12025-08-20T03:27:36ZengMDPI AGProceedings2504-39002023-08-01881910.3390/proceedings2023088009Serum Antioxidant (Vitamin E and Glutathione) in Pre-Senile Cataract Patients and healthy control in Gaza, Palestine: A Case–Control StudySujod F. Aljazzar0Marwan O. Jalambo1Kanan M. Wahedy2Ministry of Agriculture, Gaza P.O. Box 197, PalestineNutrition Sciences and Public Health, Palestine Technical College, Deir Al-Balah P.O. Box 6037, PalestineFaculty of Pharmacy, Al-Azhar University Gaza (AUG), Gaza P.O. Box 405, PalestinePre-senile cataract is the opacity of the crystalline lens of the eye before the age of 50 years. Recently, the incidence of early-onset cataracts has been on the rise. It is closely linked with oxidative stress and antioxidant deficiency. To identify the relationship between serum antioxidant levels (vitamin E and glutathione) and the occurrence of pre-senile cataract, to measure serum vitamin E and glutathione levels in patients with pre-senile cataract and compare them with those of people without a cataract, to determine the effect of dietary habits and socioeconomic status on pre-senile cataract patients and identify the relationship between anthropometric measurements and occurrence of pre-senile cataract, a retrospective case–control study was conducted at an eye hospital in Gaza City. The study consisted of 44 cases of pre-senile cataract patients and 44 cases of region-, sex-, and age-matched controls. Data collection was performed by direct methods that included anthropometric measurement and serum vitamin E and glutathione levels and indirect methods through a structured interview questionnaire. SPSS software version 24 was used to analyze the data. Regarding serum antioxidant status, serum vitamin E and glutathione levels in pre-senile cataract patients were equal to those of healthy controls. The majority of patients were illiterate, married women. An increase in body weight and obesity had a strong association with pre-senile cataract formation. Concerning dietary factors, a high intake of fruits, meat and meat products, starchy food (grains), and healthy snacks was inversely correlated with pre-senile cataract. A direct relationship between vitamin E and glutathione was found. The study concluded that pre-senile cataract is a multifactorial disease and many risk factors (dietary factors, socio-economic factors, medical factors, and anthropometrics factors) play a role in pre-senile cataract formation.https://www.mdpi.com/2504-3900/88/1/9pre-senile cataractsantioxidantsvitamin EglutathioneGaza |
| spellingShingle | Sujod F. Aljazzar Marwan O. Jalambo Kanan M. Wahedy Serum Antioxidant (Vitamin E and Glutathione) in Pre-Senile Cataract Patients and healthy control in Gaza, Palestine: A Case–Control Study Proceedings pre-senile cataracts antioxidants vitamin E glutathione Gaza |
| title | Serum Antioxidant (Vitamin E and Glutathione) in Pre-Senile Cataract Patients and healthy control in Gaza, Palestine: A Case–Control Study |
| title_full | Serum Antioxidant (Vitamin E and Glutathione) in Pre-Senile Cataract Patients and healthy control in Gaza, Palestine: A Case–Control Study |
| title_fullStr | Serum Antioxidant (Vitamin E and Glutathione) in Pre-Senile Cataract Patients and healthy control in Gaza, Palestine: A Case–Control Study |
| title_full_unstemmed | Serum Antioxidant (Vitamin E and Glutathione) in Pre-Senile Cataract Patients and healthy control in Gaza, Palestine: A Case–Control Study |
| title_short | Serum Antioxidant (Vitamin E and Glutathione) in Pre-Senile Cataract Patients and healthy control in Gaza, Palestine: A Case–Control Study |
| title_sort | serum antioxidant vitamin e and glutathione in pre senile cataract patients and healthy control in gaza palestine a case control study |
| topic | pre-senile cataracts antioxidants vitamin E glutathione Gaza |
| url | https://www.mdpi.com/2504-3900/88/1/9 |
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