Serum Antioxidant (Vitamin E and Glutathione) in Pre-Senile Cataract Patients and healthy control in Gaza, Palestine: A Case–Control Study
Pre-senile cataract is the opacity of the crystalline lens of the eye before the age of 50 years. Recently, the incidence of early-onset cataracts has been on the rise. It is closely linked with oxidative stress and antioxidant deficiency. To identify the relationship between serum antioxidant level...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
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| Series: | Proceedings |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2504-3900/88/1/9 |
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| Summary: | Pre-senile cataract is the opacity of the crystalline lens of the eye before the age of 50 years. Recently, the incidence of early-onset cataracts has been on the rise. It is closely linked with oxidative stress and antioxidant deficiency. To identify the relationship between serum antioxidant levels (vitamin E and glutathione) and the occurrence of pre-senile cataract, to measure serum vitamin E and glutathione levels in patients with pre-senile cataract and compare them with those of people without a cataract, to determine the effect of dietary habits and socioeconomic status on pre-senile cataract patients and identify the relationship between anthropometric measurements and occurrence of pre-senile cataract, a retrospective case–control study was conducted at an eye hospital in Gaza City. The study consisted of 44 cases of pre-senile cataract patients and 44 cases of region-, sex-, and age-matched controls. Data collection was performed by direct methods that included anthropometric measurement and serum vitamin E and glutathione levels and indirect methods through a structured interview questionnaire. SPSS software version 24 was used to analyze the data. Regarding serum antioxidant status, serum vitamin E and glutathione levels in pre-senile cataract patients were equal to those of healthy controls. The majority of patients were illiterate, married women. An increase in body weight and obesity had a strong association with pre-senile cataract formation. Concerning dietary factors, a high intake of fruits, meat and meat products, starchy food (grains), and healthy snacks was inversely correlated with pre-senile cataract. A direct relationship between vitamin E and glutathione was found. The study concluded that pre-senile cataract is a multifactorial disease and many risk factors (dietary factors, socio-economic factors, medical factors, and anthropometrics factors) play a role in pre-senile cataract formation. |
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| ISSN: | 2504-3900 |