Tissue specific role of ABCA1 in lung cholesterol homeostasis under high-cholesterol diet

Tissue specific role of ABCA1 in lung cholesterol homeostasis under high-cholesterol diet

BackgroundATP-binding cassette subfamily A1 (ABCA1) and sterol 27-hydroxylase (CYP27A1) are essential regulators of cholesterol metabolism. However, their tissue-specific roles, particularly in the lung, under high-cholesterol diet (HCD) conditions remain unclear.ObjectiveUsing the liver as a refere...

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Bibliographic Details
Main Authors: Jian Ma, Zhongwen Gong, Hong Lu, Han Yang, Shengquan Wang, Qian Zhu, Hongya Liu, Yongjia Li, Yuemei Zhang, Xuemei Lian
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Nutrition
Subjects:
ABCA1
cholesterol homeostasis
lung metabolism
high-cholesterol diet
tissue specificity
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2025.1649407/full
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