Clinical associations and potential cellular mechanisms linking G6PD deficiency and atherosclerotic cardiovascular disease
Abstract Glucose 6-phosphate dehydrogenase deficiency (G6PD-d) is the most common enzymopathy in the world, occurring in 5–8% of the global population (half a billion people). Recent epidemiological evidence suggests that G6PD-d may be associated with increased cardiovascular disease (CVD). Atherosc...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-04-01
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| Series: | npj Metabolic Health and Disease |
| Online Access: | https://doi.org/10.1038/s44324-025-00061-6 |
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| author | Patrick H. Andrews James C. Zimring Coleen A. McNamara |
| author_facet | Patrick H. Andrews James C. Zimring Coleen A. McNamara |
| author_sort | Patrick H. Andrews |
| collection | DOAJ |
| description | Abstract Glucose 6-phosphate dehydrogenase deficiency (G6PD-d) is the most common enzymopathy in the world, occurring in 5–8% of the global population (half a billion people). Recent epidemiological evidence suggests that G6PD-d may be associated with increased cardiovascular disease (CVD). Atherosclerosis is the dominant cause of CVD, including myocardial infarction, heart failure, stroke, and peripheral artery disease. Atherosclerosis, in turn, is a chronic inflammatory disease, fueled by oxidized lipids and influenced by various immune and nonimmune cells including vascular endothelial and smooth muscle cells, monocytes and macrophages, T cells, B cells, and red blood cells. Here, we review the existing epidemiological evidence supporting a role for G6PD-d in CVD in humans and explore the data on potential cellular mechanisms by which G6PD-d may exacerbate atherosclerosis. |
| format | Article |
| id | doaj-art-7554ccdebf974588b00a84151e868dac |
| institution | OA Journals |
| issn | 2948-2828 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Metabolic Health and Disease |
| spelling | doaj-art-7554ccdebf974588b00a84151e868dac2025-08-20T02:19:07ZengNature Portfolionpj Metabolic Health and Disease2948-28282025-04-013111510.1038/s44324-025-00061-6Clinical associations and potential cellular mechanisms linking G6PD deficiency and atherosclerotic cardiovascular diseasePatrick H. Andrews0James C. Zimring1Coleen A. McNamara2Beirne B. Carter Center for Immunology ResearchBeirne B. Carter Center for Immunology ResearchBeirne B. Carter Center for Immunology ResearchAbstract Glucose 6-phosphate dehydrogenase deficiency (G6PD-d) is the most common enzymopathy in the world, occurring in 5–8% of the global population (half a billion people). Recent epidemiological evidence suggests that G6PD-d may be associated with increased cardiovascular disease (CVD). Atherosclerosis is the dominant cause of CVD, including myocardial infarction, heart failure, stroke, and peripheral artery disease. Atherosclerosis, in turn, is a chronic inflammatory disease, fueled by oxidized lipids and influenced by various immune and nonimmune cells including vascular endothelial and smooth muscle cells, monocytes and macrophages, T cells, B cells, and red blood cells. Here, we review the existing epidemiological evidence supporting a role for G6PD-d in CVD in humans and explore the data on potential cellular mechanisms by which G6PD-d may exacerbate atherosclerosis.https://doi.org/10.1038/s44324-025-00061-6 |
| spellingShingle | Patrick H. Andrews James C. Zimring Coleen A. McNamara Clinical associations and potential cellular mechanisms linking G6PD deficiency and atherosclerotic cardiovascular disease npj Metabolic Health and Disease |
| title | Clinical associations and potential cellular mechanisms linking G6PD deficiency and atherosclerotic cardiovascular disease |
| title_full | Clinical associations and potential cellular mechanisms linking G6PD deficiency and atherosclerotic cardiovascular disease |
| title_fullStr | Clinical associations and potential cellular mechanisms linking G6PD deficiency and atherosclerotic cardiovascular disease |
| title_full_unstemmed | Clinical associations and potential cellular mechanisms linking G6PD deficiency and atherosclerotic cardiovascular disease |
| title_short | Clinical associations and potential cellular mechanisms linking G6PD deficiency and atherosclerotic cardiovascular disease |
| title_sort | clinical associations and potential cellular mechanisms linking g6pd deficiency and atherosclerotic cardiovascular disease |
| url | https://doi.org/10.1038/s44324-025-00061-6 |
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