‘Barrier dysfunction in Atopic newBorns studY’ (BABY): protocol of a Danish prospective birth cohort study
Introduction Skin barrier development and dysfunction in premature and mature newborns is important for the risk of atopic dermatitis (AD).Methods and analysis The Barrier dysfunction in Atopic newBorns studY (BABY) Cohort is a prospective birth cohort study of 150 preterm children (gestational age...
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BMJ Publishing Group
2020-07-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/7/e033801.full |
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| author | Jacob P Thyssen Trine Gerner Sanja Kezic Lone Skov Anne-Sofie Halling Maria Rasmussen Rinnov Nina Haarup Ravn Mette Hjorslev Knudgaard Charlotte Menné Bonefeld Caroline Ewertsen Simon Trautner Ivone Jakaša |
| author_facet | Jacob P Thyssen Trine Gerner Sanja Kezic Lone Skov Anne-Sofie Halling Maria Rasmussen Rinnov Nina Haarup Ravn Mette Hjorslev Knudgaard Charlotte Menné Bonefeld Caroline Ewertsen Simon Trautner Ivone Jakaša |
| author_sort | Jacob P Thyssen |
| collection | DOAJ |
| description | Introduction Skin barrier development and dysfunction in premature and mature newborns is important for the risk of atopic dermatitis (AD).Methods and analysis The Barrier dysfunction in Atopic newBorns studY (BABY) Cohort is a prospective birth cohort study of 150 preterm children (gestational age (GA) below 37+0) and 300 term children (GA 37+0 to 41+6). Skin barrier is assessed through transepidermal water loss, tape stripping, Raman-spectroscopy and microbiome sampling. Clinical examinations are done and DNA from buccal swabs is collected for genetic analyses. Thymus size is assessed by ultrasound examination. Information on pregnancy, delivery, parental exposures and diseases are collected, and structured telephone interviews are conducted at 18 and 24 months to assess exogenous exposures in the child and onset of AD. Hanifin and Rajka criteria as well as The UK Working Party's Diagnostic Criteria for Atopic Dermatitis are used to diagnose AD. Severity of AD is assessed using the Eczema Area and Severity Index (EASI) and Patient Oriented Eczema Measure (POEM).Ethics and dissemination The study is approved by the scientific Ethical Committee of the Capital Region (H-16042289 and H-16042294).Outcomes will be presented at national and international conferences and in peer-reviewed publications. |
| format | Article |
| id | doaj-art-754fdb177a3448409ad5713ac2f4be41 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-754fdb177a3448409ad5713ac2f4be412025-08-20T02:36:02ZengBMJ Publishing GroupBMJ Open2044-60552020-07-0110710.1136/bmjopen-2019-033801‘Barrier dysfunction in Atopic newBorns studY’ (BABY): protocol of a Danish prospective birth cohort studyJacob P Thyssen0Trine Gerner1Sanja Kezic2Lone Skov3Anne-Sofie Halling4Maria Rasmussen Rinnov5Nina Haarup Ravn6Mette Hjorslev Knudgaard7Charlotte Menné Bonefeld8Caroline Ewertsen9Simon Trautner10Ivone Jakaša11National Allergy Research Centre, Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, Copenhagen, DenmarkDepartment of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark3 National Expertise Centre for Substance-related Occupational Diseases (Lexces), Bilthoven, NetherlandsCopenhagen Research Group for Inflammatory Skin (CORGIS), Herlev and Gentofte Hospital, Hellerup, Denmark1 Department of Dermatology and Venerology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, DenmarkDepartment of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, DenmarkCopenhagen Research Group for Inflammatory Skin (CORGIS), Herlev and Gentofte Hospital, Hellerup, DenmarkDepartment of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, DenmarkDepartment of Immunology and Microbiology, Skin Immunology Research Center, University of Copenhagen, Copenhagen, DenmarkDepartment of Radiology, Rigshospitalet, University of Copenhagen, Copenhagen, DenmarkDepartment of Neonatology, Rigshospitalet, University of Copenhagen, Kobenhavn, Denmark3 Laboratory for Analytical Chemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, CroatiaIntroduction Skin barrier development and dysfunction in premature and mature newborns is important for the risk of atopic dermatitis (AD).Methods and analysis The Barrier dysfunction in Atopic newBorns studY (BABY) Cohort is a prospective birth cohort study of 150 preterm children (gestational age (GA) below 37+0) and 300 term children (GA 37+0 to 41+6). Skin barrier is assessed through transepidermal water loss, tape stripping, Raman-spectroscopy and microbiome sampling. Clinical examinations are done and DNA from buccal swabs is collected for genetic analyses. Thymus size is assessed by ultrasound examination. Information on pregnancy, delivery, parental exposures and diseases are collected, and structured telephone interviews are conducted at 18 and 24 months to assess exogenous exposures in the child and onset of AD. Hanifin and Rajka criteria as well as The UK Working Party's Diagnostic Criteria for Atopic Dermatitis are used to diagnose AD. Severity of AD is assessed using the Eczema Area and Severity Index (EASI) and Patient Oriented Eczema Measure (POEM).Ethics and dissemination The study is approved by the scientific Ethical Committee of the Capital Region (H-16042289 and H-16042294).Outcomes will be presented at national and international conferences and in peer-reviewed publications.https://bmjopen.bmj.com/content/10/7/e033801.full |
| spellingShingle | Jacob P Thyssen Trine Gerner Sanja Kezic Lone Skov Anne-Sofie Halling Maria Rasmussen Rinnov Nina Haarup Ravn Mette Hjorslev Knudgaard Charlotte Menné Bonefeld Caroline Ewertsen Simon Trautner Ivone Jakaša ‘Barrier dysfunction in Atopic newBorns studY’ (BABY): protocol of a Danish prospective birth cohort study BMJ Open |
| title | ‘Barrier dysfunction in Atopic newBorns studY’ (BABY): protocol of a Danish prospective birth cohort study |
| title_full | ‘Barrier dysfunction in Atopic newBorns studY’ (BABY): protocol of a Danish prospective birth cohort study |
| title_fullStr | ‘Barrier dysfunction in Atopic newBorns studY’ (BABY): protocol of a Danish prospective birth cohort study |
| title_full_unstemmed | ‘Barrier dysfunction in Atopic newBorns studY’ (BABY): protocol of a Danish prospective birth cohort study |
| title_short | ‘Barrier dysfunction in Atopic newBorns studY’ (BABY): protocol of a Danish prospective birth cohort study |
| title_sort | barrier dysfunction in atopic newborns study baby protocol of a danish prospective birth cohort study |
| url | https://bmjopen.bmj.com/content/10/7/e033801.full |
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