Causal links between iron status, mitochondrial function, and laryngeal and hypopharyngeal cancers: a Mendelian study

Causal links between iron status, mitochondrial function, and laryngeal and hypopharyngeal cancers: a Mendelian study

Abstract Background This Mendelian randomization (MR) study aimed to investigate bidirectional causal relationships between genetically predicted iron homeostasis, mitochondrial function, and the risk of laryngeal and hypopharyngeal cancers. Methods Summary-level data were extracted from genome-wide...

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Bibliographic Details
Main Authors: Jiandong Zhao, Liwei Chen, Bing Han, Siyang Li, Yongxia Zhang, Ge Gao, Jinjing Liu
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Discover Oncology
Subjects:
Mendelian randomization
Iron metabolism
Mitochondrial function
Laryngeal cancer
Hypopharyngeal cancer
Sirtuin-5
Online Access:https://doi.org/10.1007/s12672-025-03187-7
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