Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis
Metastasis is a multistep process including dissociation of cancer cells from primary sites, survival in the vascular system, and proliferation in distant target organs. As a barrier to metastasis, cells normally undergo an apoptotic process known as “anoikis,” a form of cell death due to loss of co...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/306879 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849410678698278912 |
|---|---|
| author | Yong-Nyun Kim Kyung Hee Koo Jee Young Sung Un-Jung Yun Hyeryeong Kim |
| author_facet | Yong-Nyun Kim Kyung Hee Koo Jee Young Sung Un-Jung Yun Hyeryeong Kim |
| author_sort | Yong-Nyun Kim |
| collection | DOAJ |
| description | Metastasis is a multistep process including dissociation of cancer cells from primary sites, survival in the vascular system, and proliferation in distant target organs. As a barrier to metastasis, cells normally undergo an apoptotic process known as “anoikis,” a form of cell death due to loss of contact with the extracellular matrix or neighboring cells. Cancer cells acquire anoikis resistance to survive after detachment from the primary sites and travel through the circulatory and lymphatic systems to disseminate throughout the body. Because recent technological advances enable us to detect rare circulating tumor cells, which are anoikis resistant, currently, anoikis resistance becomes a hot topic in cancer research. Detailed molecular and functional analyses of anoikis resistant cells may provide insight into the biology of cancer metastasis and identify novel therapeutic targets for prevention of cancer dissemination. This paper comprehensively describes recent investigations of the molecular and cellular mechanisms underlying anoikis and anoikis resistance in relation to intrinsic and extrinsic death signaling, epithelial-mesenchymal transition, growth factor receptors, energy metabolism, reactive oxygen species, membrane microdomains, and lipid rafts. |
| format | Article |
| id | doaj-art-754c40f1695b482facef0d162e191da7 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-754c40f1695b482facef0d162e191da72025-08-20T03:35:01ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/306879306879Anoikis Resistance: An Essential Prerequisite for Tumor MetastasisYong-Nyun Kim0Kyung Hee Koo1Jee Young Sung2Un-Jung Yun3Hyeryeong Kim4Pediatric Oncology Branch, National Cancer Center, 323 Ilsan-Ro, Ilsandong-Gu, Gyeonggi-Do, Goyang-Si 410-769, Republic of KoreaPediatric Oncology Branch, National Cancer Center, 323 Ilsan-Ro, Ilsandong-Gu, Gyeonggi-Do, Goyang-Si 410-769, Republic of KoreaPediatric Oncology Branch, National Cancer Center, 323 Ilsan-Ro, Ilsandong-Gu, Gyeonggi-Do, Goyang-Si 410-769, Republic of KoreaPediatric Oncology Branch, National Cancer Center, 323 Ilsan-Ro, Ilsandong-Gu, Gyeonggi-Do, Goyang-Si 410-769, Republic of KoreaPediatric Oncology Branch, National Cancer Center, 323 Ilsan-Ro, Ilsandong-Gu, Gyeonggi-Do, Goyang-Si 410-769, Republic of KoreaMetastasis is a multistep process including dissociation of cancer cells from primary sites, survival in the vascular system, and proliferation in distant target organs. As a barrier to metastasis, cells normally undergo an apoptotic process known as “anoikis,” a form of cell death due to loss of contact with the extracellular matrix or neighboring cells. Cancer cells acquire anoikis resistance to survive after detachment from the primary sites and travel through the circulatory and lymphatic systems to disseminate throughout the body. Because recent technological advances enable us to detect rare circulating tumor cells, which are anoikis resistant, currently, anoikis resistance becomes a hot topic in cancer research. Detailed molecular and functional analyses of anoikis resistant cells may provide insight into the biology of cancer metastasis and identify novel therapeutic targets for prevention of cancer dissemination. This paper comprehensively describes recent investigations of the molecular and cellular mechanisms underlying anoikis and anoikis resistance in relation to intrinsic and extrinsic death signaling, epithelial-mesenchymal transition, growth factor receptors, energy metabolism, reactive oxygen species, membrane microdomains, and lipid rafts.http://dx.doi.org/10.1155/2012/306879 |
| spellingShingle | Yong-Nyun Kim Kyung Hee Koo Jee Young Sung Un-Jung Yun Hyeryeong Kim Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis International Journal of Cell Biology |
| title | Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis |
| title_full | Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis |
| title_fullStr | Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis |
| title_full_unstemmed | Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis |
| title_short | Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis |
| title_sort | anoikis resistance an essential prerequisite for tumor metastasis |
| url | http://dx.doi.org/10.1155/2012/306879 |
| work_keys_str_mv | AT yongnyunkim anoikisresistanceanessentialprerequisitefortumormetastasis AT kyungheekoo anoikisresistanceanessentialprerequisitefortumormetastasis AT jeeyoungsung anoikisresistanceanessentialprerequisitefortumormetastasis AT unjungyun anoikisresistanceanessentialprerequisitefortumormetastasis AT hyeryeongkim anoikisresistanceanessentialprerequisitefortumormetastasis |