Simultaneous determination of lesinurad and co-administered drugs used in management of gout comorbidities to uncover potential pharmacokinetic interaction in rat plasma

Abstract Gout is one of the most prevalent forms of arthritis that is usually accompanied by other comorbidities. For this reason, multiple drugs are routinely prescribed for gout patients, which may affect the clinical course outcomes, and increase the risk of drug-drug interactions. This work pres...

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Bibliographic Details
Main Authors: Hadeel A. Khalil, Amira F. El-Yazbi, Eman I. El-Kimary, Mohamed A. Elrewiny, Ahmed F. El-Yazbi, Tarek S. Belal
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-93680-4
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