Autoregulation of the real-time kinetics of the human mitochondrial replicative helicase

Autoregulation of the real-time kinetics of the human mitochondrial replicative helicase

Abstract The human mitochondrial helicase Twinkle is essential for mitochondrial DNA (mtDNA) replication and integrity. Using biochemical and single-molecule techniques, we investigated Twinkle’s real-time kinetics, including DNA loading, unwinding, and rewinding, and their regulation by its N-termi...

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Main Authors: Ismael Plaza-G A, María Ortiz-Rodríguez, Seth P. Buchanan, Samuel Miguez-Amil, Kateryna M. Lemishko, Fernando Moreno-Herrero, Rafael Fernandez-Leiro, Grzegorz L. Ciesielski, Borja Ibarra
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60289-0
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