Elevated CEA and CA 19-9 Levels within the Normal Ranges Increase the Likelihood of CRC Recurrence in the Chinese Han Population
Objective. This study aimed to determine if variations in the expression profiles of CA 19-9 and carcinoembryonic antigen (CEA) within the reference range could serve as possible biomarkers for postoperative CRC recurrence. Method. This retrospective cohort investigation enrolled 2,596 cases of CRC...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Applied Bionics and Biomechanics |
| Online Access: | http://dx.doi.org/10.1155/2022/8666724 |
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| author | Lujia Wang Guangkai Zhang Jiafeng Shen Yujiang Shen Guojun Cai |
| author_facet | Lujia Wang Guangkai Zhang Jiafeng Shen Yujiang Shen Guojun Cai |
| author_sort | Lujia Wang |
| collection | DOAJ |
| description | Objective. This study aimed to determine if variations in the expression profiles of CA 19-9 and carcinoembryonic antigen (CEA) within the reference range could serve as possible biomarkers for postoperative CRC recurrence. Method. This retrospective cohort investigation enrolled 2,596 cases of CRC that received curative surgery. Serum CEA/CA 19-9 were measured through chemiluminescence immunoassay (CLIA). Results. During follow-up (median follow-up = 5.2 years), in total, 837 patients experienced recurrence. The fully adjusted hazard ratios (HRs) were significantly higher, ≥1 standard deviation (±SD), in patients with upregulated CEA/CA 19-9 levels (HRCEA=7.06; HRCA 19−9=3.98) than in those with downregulated CEA/CA 19-9 levels. The likelihood of recurrence remained consistently greater in cases of elevated CEA/CA 19-9 levels during sensitivity analyses. Conclusions. The findings of this analysis showed that variations in CEA/CA 19-9 expression profiles within the reference range impact CRC recurrence. |
| format | Article |
| id | doaj-art-7545f7d136a648e4b028b510cc229bc7 |
| institution | Kabale University |
| issn | 1754-2103 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Applied Bionics and Biomechanics |
| spelling | doaj-art-7545f7d136a648e4b028b510cc229bc72025-08-20T03:35:01ZengWileyApplied Bionics and Biomechanics1754-21032022-01-01202210.1155/2022/8666724Elevated CEA and CA 19-9 Levels within the Normal Ranges Increase the Likelihood of CRC Recurrence in the Chinese Han PopulationLujia Wang0Guangkai Zhang1Jiafeng Shen2Yujiang Shen3Guojun Cai4Department of Anus and IntestineDepartment of Anus and IntestineDepartment of Anus and IntestineDepartment of Anus and IntestineDepartment of Anus and IntestineObjective. This study aimed to determine if variations in the expression profiles of CA 19-9 and carcinoembryonic antigen (CEA) within the reference range could serve as possible biomarkers for postoperative CRC recurrence. Method. This retrospective cohort investigation enrolled 2,596 cases of CRC that received curative surgery. Serum CEA/CA 19-9 were measured through chemiluminescence immunoassay (CLIA). Results. During follow-up (median follow-up = 5.2 years), in total, 837 patients experienced recurrence. The fully adjusted hazard ratios (HRs) were significantly higher, ≥1 standard deviation (±SD), in patients with upregulated CEA/CA 19-9 levels (HRCEA=7.06; HRCA 19−9=3.98) than in those with downregulated CEA/CA 19-9 levels. The likelihood of recurrence remained consistently greater in cases of elevated CEA/CA 19-9 levels during sensitivity analyses. Conclusions. The findings of this analysis showed that variations in CEA/CA 19-9 expression profiles within the reference range impact CRC recurrence.http://dx.doi.org/10.1155/2022/8666724 |
| spellingShingle | Lujia Wang Guangkai Zhang Jiafeng Shen Yujiang Shen Guojun Cai Elevated CEA and CA 19-9 Levels within the Normal Ranges Increase the Likelihood of CRC Recurrence in the Chinese Han Population Applied Bionics and Biomechanics |
| title | Elevated CEA and CA 19-9 Levels within the Normal Ranges Increase the Likelihood of CRC Recurrence in the Chinese Han Population |
| title_full | Elevated CEA and CA 19-9 Levels within the Normal Ranges Increase the Likelihood of CRC Recurrence in the Chinese Han Population |
| title_fullStr | Elevated CEA and CA 19-9 Levels within the Normal Ranges Increase the Likelihood of CRC Recurrence in the Chinese Han Population |
| title_full_unstemmed | Elevated CEA and CA 19-9 Levels within the Normal Ranges Increase the Likelihood of CRC Recurrence in the Chinese Han Population |
| title_short | Elevated CEA and CA 19-9 Levels within the Normal Ranges Increase the Likelihood of CRC Recurrence in the Chinese Han Population |
| title_sort | elevated cea and ca 19 9 levels within the normal ranges increase the likelihood of crc recurrence in the chinese han population |
| url | http://dx.doi.org/10.1155/2022/8666724 |
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