Evaluating IL-21 as a Potential Therapeutic Target in Crohn’s Disease

Evaluating IL-21 as a Potential Therapeutic Target in Crohn’s Disease

Background and Aim. Interleukin-21 (IL-21) is primarily a T cell-derived cytokine; it is upregulated in patients with Crohn’s Disease (CD) and could be a potential new therapeutic target in CD. Methods. In human material, IL-21 and IL-21R expression was investigated by in situ hybridization (ISH) an...

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Main Authors: Thomas Lindebo Holm, Ditte Tornehave, Henrik Søndergaard, Peter Helding Kvist, Bodil-Cecilie Sondergaard, Lene Hansen, Mette Brunsgaard Hermit, Kristine Holgersen, Sandra Vergo, Klaus Stensgaard Frederiksen, Claus Haase, Dorthe Lundsgaard
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Gastroenterology Research and Practice
Online Access:http://dx.doi.org/10.1155/2018/5962624
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