The Interplay between Zinc, Vitamin D and, IL-17 in Patients with Chronic Hepatitis C Liver Disease
Objectives. To assess zinc (Zn) and vitamin D (Vit. D) status in chronic Hepatitis C virus- (HCV) infected patients and their relationship to interleukin- (IL-) 17 and disease severity and then investigate whether Zn and Vit. D3 modulate IL-17 expression in chronic HCV patients. Methods. Seventy pat...
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| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/846348 |
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| author | Randa Reda Amal A. Abbas Mai Mohammed Shahira F. El Fedawy Hala Ghareeb Rania H. El Kabarity Rania A. Abo-Shady Doaa Zakaria |
| author_facet | Randa Reda Amal A. Abbas Mai Mohammed Shahira F. El Fedawy Hala Ghareeb Rania H. El Kabarity Rania A. Abo-Shady Doaa Zakaria |
| author_sort | Randa Reda |
| collection | DOAJ |
| description | Objectives. To assess zinc (Zn) and vitamin D (Vit. D) status in chronic Hepatitis C virus- (HCV) infected patients and their relationship to interleukin- (IL-) 17 and disease severity and then investigate whether Zn and Vit. D3 modulate IL-17 expression in chronic HCV patients. Methods. Seventy patients and fifty healthy subjects were investigated. Serum levels of Zn, Vit. D, and IL-17 were assessed in the patients group and subgroups. Patients lymphocytes were activated in vitro in the presence or absence of Zn or Vit. D3 and then intracellular IL-17 production was assessed using flow cytometry. Results. Zn and Vit. D were significantly decreased in HCV patients. Increasing disease severity leads to more reduction in Zn level opposed by increasing IL-17 level. Zn potently reduced IL-17 production in a dose-related fashion; however it did not exert any toxic effects. Although Vit. D apparently increases IL17 expression, it is unclear whether it is due to its toxic effect on cell count or lack of definite association between Vit. D and both IL-17 and disease severity. Conclusions. This study demonstrates that Zn modulates IL-17 expression and provides a rationale for evaluating this compound as a supplementary agent in the treatment of chronic HCV. |
| format | Article |
| id | doaj-art-753ffd4fec4c47a68efb71722158c335 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-753ffd4fec4c47a68efb71722158c3352025-08-20T02:06:50ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/846348846348The Interplay between Zinc, Vitamin D and, IL-17 in Patients with Chronic Hepatitis C Liver DiseaseRanda Reda0Amal A. Abbas1Mai Mohammed2Shahira F. El Fedawy3Hala Ghareeb4Rania H. El Kabarity5Rania A. Abo-Shady6Doaa Zakaria7Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Abbassia Square, P.O. Box 11566, Cairo, EgyptClinical Pathology Department, Faculty of Medicine, Ain Shams University, Abbassia Square, P.O. Box 11566, Cairo, EgyptClinical Pathology Department, Faculty of Medicine, Ain Shams University, Abbassia Square, P.O. Box 11566, Cairo, EgyptClinical Pathology Department, Faculty of Medicine, Ain Shams University, Abbassia Square, P.O. Box 11566, Cairo, EgyptClinical Pathology Department, Faculty of Medicine, Ain Shams University, Abbassia Square, P.O. Box 11566, Cairo, EgyptClinical Pathology Department, Faculty of Medicine, Ain Shams University, Abbassia Square, P.O. Box 11566, Cairo, EgyptClinical Pathology Department, Faculty of Medicine, Ain Shams University, Abbassia Square, P.O. Box 11566, Cairo, EgyptTropical Medicine Department, Faculty of Medicine, Ain Shams University, Abbassia Square, P.O. Box 11566, Cairo, EgyptObjectives. To assess zinc (Zn) and vitamin D (Vit. D) status in chronic Hepatitis C virus- (HCV) infected patients and their relationship to interleukin- (IL-) 17 and disease severity and then investigate whether Zn and Vit. D3 modulate IL-17 expression in chronic HCV patients. Methods. Seventy patients and fifty healthy subjects were investigated. Serum levels of Zn, Vit. D, and IL-17 were assessed in the patients group and subgroups. Patients lymphocytes were activated in vitro in the presence or absence of Zn or Vit. D3 and then intracellular IL-17 production was assessed using flow cytometry. Results. Zn and Vit. D were significantly decreased in HCV patients. Increasing disease severity leads to more reduction in Zn level opposed by increasing IL-17 level. Zn potently reduced IL-17 production in a dose-related fashion; however it did not exert any toxic effects. Although Vit. D apparently increases IL17 expression, it is unclear whether it is due to its toxic effect on cell count or lack of definite association between Vit. D and both IL-17 and disease severity. Conclusions. This study demonstrates that Zn modulates IL-17 expression and provides a rationale for evaluating this compound as a supplementary agent in the treatment of chronic HCV.http://dx.doi.org/10.1155/2015/846348 |
| spellingShingle | Randa Reda Amal A. Abbas Mai Mohammed Shahira F. El Fedawy Hala Ghareeb Rania H. El Kabarity Rania A. Abo-Shady Doaa Zakaria The Interplay between Zinc, Vitamin D and, IL-17 in Patients with Chronic Hepatitis C Liver Disease Journal of Immunology Research |
| title | The Interplay between Zinc, Vitamin D and, IL-17 in Patients with Chronic Hepatitis C Liver Disease |
| title_full | The Interplay between Zinc, Vitamin D and, IL-17 in Patients with Chronic Hepatitis C Liver Disease |
| title_fullStr | The Interplay between Zinc, Vitamin D and, IL-17 in Patients with Chronic Hepatitis C Liver Disease |
| title_full_unstemmed | The Interplay between Zinc, Vitamin D and, IL-17 in Patients with Chronic Hepatitis C Liver Disease |
| title_short | The Interplay between Zinc, Vitamin D and, IL-17 in Patients with Chronic Hepatitis C Liver Disease |
| title_sort | interplay between zinc vitamin d and il 17 in patients with chronic hepatitis c liver disease |
| url | http://dx.doi.org/10.1155/2015/846348 |
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