Taurine alleviates dysfunction of cholesterol metabolism under hyperuricemia by inhibiting A2AR-SREBP-2/CREB/HMGCR axis

Taurine alleviates dysfunction of cholesterol metabolism under hyperuricemia by inhibiting A2AR-SREBP-2/CREB/HMGCR axis

Dysfunctional cholesterol metabolism is highly prevalent in patients with hyperuricemia. Both uric acid and cholesterol are independent risk factors for atherosclerosis, contributing to an increased incidence of cardiovascular disease in hyperuricemia. Investigating the pathological mechanisms under...

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Bibliographic Details
Main Authors: Beibei Chen, Ruixia Bao, Jujie Pan, Zicheng Zhu, Qian Chen, Dan Wang, Yuzheng Wu, Haiyang Yu, Yi Zhang, Tao Wang
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Journal of Lipid Research
Subjects:
taurine
hyperuricemia
cholesterol
adenosine A2A receptor
HMGCR
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227525000069
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