The Impact of Creatine Supplementation on Physical Performance, Cognitive Functions, and Safety – A Literature Review
Purpose of Research: The study evaluates the effects of creatine supplementation on physical performance, cognitive function, and safety. It examines its mechanism of action, impact on muscle mass and strength, and role in brain health. Additionally, it reviews the safety profile of creatine in div...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-02-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/58256 |
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| author | Adam Sobiński Matylda Czerwonka Zuzanna Kościuszko Katarzyna Kurza Silvia Ciraolo Julianna Podolec Agnieszka Kulczycka-Rowicka Katarzyna Lesiczka-Fedoryj Joanna Wojda Anna Walczak |
| author_facet | Adam Sobiński Matylda Czerwonka Zuzanna Kościuszko Katarzyna Kurza Silvia Ciraolo Julianna Podolec Agnieszka Kulczycka-Rowicka Katarzyna Lesiczka-Fedoryj Joanna Wojda Anna Walczak |
| author_sort | Adam Sobiński |
| collection | DOAJ |
| description |
Purpose of Research: The study evaluates the effects of creatine supplementation on physical performance, cognitive function, and safety. It examines its mechanism of action, impact on muscle mass and strength, and role in brain health. Additionally, it reviews the safety profile of creatine in diverse populations, including athletes, older adults, and individuals with chronic conditions.
Research Materials and Methods: The study is based on clinical trials, meta-analyses, and systematic reviews from the past decade. Data were collected from studies on creatine supplementation at various doses, including loading and maintenance phases, and its effects on physical and cognitive outcomes, as well as kidney and liver function.
Basic Results Creatine supplementation significantly improved lean body mass (mean difference = 1.32 kg; p < 0.000001) and muscle strength, with greater effects in men. It also showed potential benefits for memory, particularly in older adults, with moderate improvements in non-stress conditions. Safety evaluations indicated no adverse effects on kidney or liver function, even with long-term high-dose use.
Conclusions: Creatine supplementation is a safe, effective strategy for enhancing physical performance, especially with resistance training. It also supports cognitive functions, particularly in populations with higher energy demands or age-related decline. These findings support creatine as a versatile, well-tolerated dietary supplement for sports and health applications.
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| format | Article |
| id | doaj-art-753988ae47a4402992936ce2b1781663 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-753988ae47a4402992936ce2b17816632025-02-12T08:26:11ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-02-013810.12775/QS.2025.58.58256The Impact of Creatine Supplementation on Physical Performance, Cognitive Functions, and Safety – A Literature ReviewAdam Sobiński0https://orcid.org/0009-0003-3063-5621Matylda Czerwonka1https://orcid.org/0009-0000-9738-9646Zuzanna Kościuszko2https://orcid.org/0009-0008-1490-8569Katarzyna Kurza3https://orcid.org/0009-0009-0075-2257Silvia Ciraolo4https://orcid.org/0009-0005-7010-5195Julianna Podolec5https://orcid.org/0009-0000-6980-7046Agnieszka Kulczycka-Rowicka6https://orcid.org/0009-0009-8917-4042Katarzyna Lesiczka-Fedoryj7https://orcid.org/0009-0004-4213-3028Joanna Wojda8https://orcid.org/0009-0006-2662-8893Anna Walczak9https://orcid.org/0009-0004-4554-9598MEDAR Private Healthcare Facility in LeczycaŚniadeckiego Voivodeship Hospital in BiałystokFlorian Ceynowy Specialist Hospital in Wejherowo: Wejherowo, PLIndependent Public Health Care Facility in MysleniceUniversity Clinical Hospital in Bialystok: Bialystok, PL Maria Skłodowska- Curie 24A, 15-276 BialystokUniversity Clinical Hospital in BialystokŚniadeckiego Voivodeship Hospital in Bialystok: BiałystokHospital in Puszczykowo: Puszczykowo, PLUniversity Clinical Hospital in Bialystok: Białystok, PL Maria Skłodowska- Curie 24A, 15-276 BialystokŚniadeckiego Voivodeship Hospital in Bialystok: Białystok, PL Purpose of Research: The study evaluates the effects of creatine supplementation on physical performance, cognitive function, and safety. It examines its mechanism of action, impact on muscle mass and strength, and role in brain health. Additionally, it reviews the safety profile of creatine in diverse populations, including athletes, older adults, and individuals with chronic conditions. Research Materials and Methods: The study is based on clinical trials, meta-analyses, and systematic reviews from the past decade. Data were collected from studies on creatine supplementation at various doses, including loading and maintenance phases, and its effects on physical and cognitive outcomes, as well as kidney and liver function. Basic Results Creatine supplementation significantly improved lean body mass (mean difference = 1.32 kg; p < 0.000001) and muscle strength, with greater effects in men. It also showed potential benefits for memory, particularly in older adults, with moderate improvements in non-stress conditions. Safety evaluations indicated no adverse effects on kidney or liver function, even with long-term high-dose use. Conclusions: Creatine supplementation is a safe, effective strategy for enhancing physical performance, especially with resistance training. It also supports cognitive functions, particularly in populations with higher energy demands or age-related decline. These findings support creatine as a versatile, well-tolerated dietary supplement for sports and health applications. https://apcz.umk.pl/QS/article/view/58256CreatineSupplementationstrength trainingbrain healthmemory |
| spellingShingle | Adam Sobiński Matylda Czerwonka Zuzanna Kościuszko Katarzyna Kurza Silvia Ciraolo Julianna Podolec Agnieszka Kulczycka-Rowicka Katarzyna Lesiczka-Fedoryj Joanna Wojda Anna Walczak The Impact of Creatine Supplementation on Physical Performance, Cognitive Functions, and Safety – A Literature Review Quality in Sport Creatine Supplementation strength training brain health memory |
| title | The Impact of Creatine Supplementation on Physical Performance, Cognitive Functions, and Safety – A Literature Review |
| title_full | The Impact of Creatine Supplementation on Physical Performance, Cognitive Functions, and Safety – A Literature Review |
| title_fullStr | The Impact of Creatine Supplementation on Physical Performance, Cognitive Functions, and Safety – A Literature Review |
| title_full_unstemmed | The Impact of Creatine Supplementation on Physical Performance, Cognitive Functions, and Safety – A Literature Review |
| title_short | The Impact of Creatine Supplementation on Physical Performance, Cognitive Functions, and Safety – A Literature Review |
| title_sort | impact of creatine supplementation on physical performance cognitive functions and safety a literature review |
| topic | Creatine Supplementation strength training brain health memory |
| url | https://apcz.umk.pl/QS/article/view/58256 |
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