Gene-Based Antibody Strategies for Prion Diseases
Prion diseases or transmissible spongiform encephalopathies (TSE) are a group of neurodegenerative and infectious disorders characterized by the conversion of a normal cellular protein PrPC into a pathological abnormally folded form, termed PrPSc. There are neither available therapies nor diagnostic...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2013/710406 |
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| author | Alessio Cardinale Silvia Biocca |
| author_facet | Alessio Cardinale Silvia Biocca |
| author_sort | Alessio Cardinale |
| collection | DOAJ |
| description | Prion diseases or transmissible spongiform encephalopathies (TSE) are a group of neurodegenerative and infectious disorders characterized by the conversion of a normal cellular protein PrPC into a pathological abnormally folded form, termed PrPSc. There are neither available therapies nor diagnostic tools for an early identification of individuals affected by these diseases. New gene-based antibody strategies are emerging as valuable therapeutic tools. Among these, intrabodies are chimeric molecules composed by recombinant antibody fragments fused to intracellular trafficking sequences, aimed at inhibiting, in vivo, the function of specific therapeutic targets. The advantage of intrabodies is that they can be selected against a precise epitope of target proteins, including protein-protein interaction sites and cytotoxic conformers (i.e., oligomeric and fibrillar assemblies). Herein, we address and discuss in vitro and in vivo applications of intrabodies in prion diseases, focussing on their therapeutic potential. |
| format | Article |
| id | doaj-art-75392c4ea4bf4a6b8deac40fbd3067b3 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-75392c4ea4bf4a6b8deac40fbd3067b32025-08-20T03:33:34ZengWileyInternational Journal of Cell Biology1687-88761687-88842013-01-01201310.1155/2013/710406710406Gene-Based Antibody Strategies for Prion DiseasesAlessio Cardinale0Silvia Biocca1IRCCS San Raffaele Pisana, Via di Val Cannuta 247, 00166 Rome, ItalyDepartment of Systems Medicine, University of Rome “Tor Vergata,” Via Montpellier 1, 00133 Rome, ItalyPrion diseases or transmissible spongiform encephalopathies (TSE) are a group of neurodegenerative and infectious disorders characterized by the conversion of a normal cellular protein PrPC into a pathological abnormally folded form, termed PrPSc. There are neither available therapies nor diagnostic tools for an early identification of individuals affected by these diseases. New gene-based antibody strategies are emerging as valuable therapeutic tools. Among these, intrabodies are chimeric molecules composed by recombinant antibody fragments fused to intracellular trafficking sequences, aimed at inhibiting, in vivo, the function of specific therapeutic targets. The advantage of intrabodies is that they can be selected against a precise epitope of target proteins, including protein-protein interaction sites and cytotoxic conformers (i.e., oligomeric and fibrillar assemblies). Herein, we address and discuss in vitro and in vivo applications of intrabodies in prion diseases, focussing on their therapeutic potential.http://dx.doi.org/10.1155/2013/710406 |
| spellingShingle | Alessio Cardinale Silvia Biocca Gene-Based Antibody Strategies for Prion Diseases International Journal of Cell Biology |
| title | Gene-Based Antibody Strategies for Prion Diseases |
| title_full | Gene-Based Antibody Strategies for Prion Diseases |
| title_fullStr | Gene-Based Antibody Strategies for Prion Diseases |
| title_full_unstemmed | Gene-Based Antibody Strategies for Prion Diseases |
| title_short | Gene-Based Antibody Strategies for Prion Diseases |
| title_sort | gene based antibody strategies for prion diseases |
| url | http://dx.doi.org/10.1155/2013/710406 |
| work_keys_str_mv | AT alessiocardinale genebasedantibodystrategiesforpriondiseases AT silviabiocca genebasedantibodystrategiesforpriondiseases |