Changes in Antibiotic Susceptibility of Helicobacter pylori in the Course of Eight Years in the Zaanstreek Region in The Netherlands
Background. Failure of anti-Helicobacter therapy is the result noncompliance and resistance to the prescribed antibiotics. Aim. Antibiotic susceptibility of H. pylori was determined in native Dutch patients and patients of Turkish descent. Methods. In a period of eight years a total of 925 strains o...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/625937 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850220967874265088 |
|---|---|
| author | R. J. L. F. Loffeld B. F. M. Werdmuller |
| author_facet | R. J. L. F. Loffeld B. F. M. Werdmuller |
| author_sort | R. J. L. F. Loffeld |
| collection | DOAJ |
| description | Background. Failure of anti-Helicobacter therapy is the result noncompliance and resistance to the prescribed antibiotics. Aim. Antibiotic susceptibility of H. pylori was determined in native Dutch patients and patients of Turkish descent. Methods. In a period of eight years a total of 925 strains of H. pylori were cultured. Bacterial susceptibility was successfully determined in 746 (80.6%) of these isolates. Three hundred and nine strains (33%) originated from patients of Turkish descent. Results. In total clarithromycin resistance was found in 146 (20.5%) strains, metronidazole resistance in 147 (19.9%) strains. Amoxicillin resistance was found to be present in five strains. There is a slight but nonsignificant decrease in the percentage of clarithromycin-resistant strains in the consecutive period of eight years from 20% to 18%. No changes were seen in the consecutive years in metronidazole resistance. The number of clarithromycin-resistant strains decreased in Turkish patients, not in native Dutch patients. Conclusion. Resistance did not change significantly in consecutive years. But clinicians should take not only the antibiotic history into account but also ethnicity before prescribing metronidazole or clarithromycin. |
| format | Article |
| id | doaj-art-7537c9db4553424390219c76cfda9bb2 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-7537c9db4553424390219c76cfda9bb22025-08-20T02:06:51ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/625937625937Changes in Antibiotic Susceptibility of Helicobacter pylori in the Course of Eight Years in the Zaanstreek Region in The NetherlandsR. J. L. F. Loffeld0B. F. M. Werdmuller1Department of Internal Medicine, Zaans Medisch Centrum, Zaandam, The NetherlandsDepartment of Microbiology, Zaans Medisch Centrum, Zaandam, The NetherlandsBackground. Failure of anti-Helicobacter therapy is the result noncompliance and resistance to the prescribed antibiotics. Aim. Antibiotic susceptibility of H. pylori was determined in native Dutch patients and patients of Turkish descent. Methods. In a period of eight years a total of 925 strains of H. pylori were cultured. Bacterial susceptibility was successfully determined in 746 (80.6%) of these isolates. Three hundred and nine strains (33%) originated from patients of Turkish descent. Results. In total clarithromycin resistance was found in 146 (20.5%) strains, metronidazole resistance in 147 (19.9%) strains. Amoxicillin resistance was found to be present in five strains. There is a slight but nonsignificant decrease in the percentage of clarithromycin-resistant strains in the consecutive period of eight years from 20% to 18%. No changes were seen in the consecutive years in metronidazole resistance. The number of clarithromycin-resistant strains decreased in Turkish patients, not in native Dutch patients. Conclusion. Resistance did not change significantly in consecutive years. But clinicians should take not only the antibiotic history into account but also ethnicity before prescribing metronidazole or clarithromycin.http://dx.doi.org/10.1155/2013/625937 |
| spellingShingle | R. J. L. F. Loffeld B. F. M. Werdmuller Changes in Antibiotic Susceptibility of Helicobacter pylori in the Course of Eight Years in the Zaanstreek Region in The Netherlands Gastroenterology Research and Practice |
| title | Changes in Antibiotic Susceptibility of Helicobacter pylori in the Course of Eight Years in the Zaanstreek Region in The Netherlands |
| title_full | Changes in Antibiotic Susceptibility of Helicobacter pylori in the Course of Eight Years in the Zaanstreek Region in The Netherlands |
| title_fullStr | Changes in Antibiotic Susceptibility of Helicobacter pylori in the Course of Eight Years in the Zaanstreek Region in The Netherlands |
| title_full_unstemmed | Changes in Antibiotic Susceptibility of Helicobacter pylori in the Course of Eight Years in the Zaanstreek Region in The Netherlands |
| title_short | Changes in Antibiotic Susceptibility of Helicobacter pylori in the Course of Eight Years in the Zaanstreek Region in The Netherlands |
| title_sort | changes in antibiotic susceptibility of helicobacter pylori in the course of eight years in the zaanstreek region in the netherlands |
| url | http://dx.doi.org/10.1155/2013/625937 |
| work_keys_str_mv | AT rjlfloffeld changesinantibioticsusceptibilityofhelicobacterpyloriinthecourseofeightyearsinthezaanstreekregioninthenetherlands AT bfmwerdmuller changesinantibioticsusceptibilityofhelicobacterpyloriinthecourseofeightyearsinthezaanstreekregioninthenetherlands |