Thyroid Stimulating Hormone Is Increased in Hypertensive Patients with Obstructive Sleep Apnea
Purpose. To evaluate alteration in serum TSH in hypertensives with OSA and its relation with cardiometabolic risk factors. Methods. 517 hypertensives were cross-sectionally studied. OSA was determined by polysomnography and thyroid function by standard methods. Results. OSA was diagnosed in 373 hype...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/4802720 |
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| author | Nanfang Li Mulalibieke Heizhati Chao Sun Suofeiya Abulikemu Liang Shao Xiaoguang Yao Yingchun Wang Jing Hong Ling Zhou Lei Wang Yu Zhang Weiwei Zhang |
| author_facet | Nanfang Li Mulalibieke Heizhati Chao Sun Suofeiya Abulikemu Liang Shao Xiaoguang Yao Yingchun Wang Jing Hong Ling Zhou Lei Wang Yu Zhang Weiwei Zhang |
| author_sort | Nanfang Li |
| collection | DOAJ |
| description | Purpose. To evaluate alteration in serum TSH in hypertensives with OSA and its relation with cardiometabolic risk factors. Methods. 517 hypertensives were cross-sectionally studied. OSA was determined by polysomnography and thyroid function by standard methods. Results. OSA was diagnosed in 373 hypertensives (72.15%). Prevalence of subclinical hypothyroidism was significantly higher in OSA hypertensives than in non-OSA ones (15.0% versus 6.9%, P=0.014). Serum LnTSH in hypertensives with severe OSA was significantly higher (0.99±0.81 versus 0.74±0.77 μIU/mL, P<0.05) than in those without OSA. AHI, LSaO2, ODI3, and ODI4 were independently associated with serum TSH for those aged 30–65 years. Dividing subjects into four groups as TSH < 1.0 μIU/mL, 1.0 ≤ THS ≤ 1.9 μIU/mL, 1.91 ≤ TSH < 4.5 μIU/mL, and TSH ≥ 4.5 μIU/mL, only 26.3% of OSA subjects exhibited TSH between 1.0 and 1.9 μIU/mL, significantly less than non-OSA subjects (26.3% versus 38.2%, P=0.01). DBP and serum LDL-c elevated with TSH increasing and were only significantly higher in TSH ≥ 4.5 μIU/mL group than in 1.0 ≤ TSH ≤ 1.9 μIU/mL group (96.32±14.19 versus 92.31±12.86 mmHg; P=0.040; 0.99±0.60 versus 0.87±0.34 mmol/L, P=0.023). Conclusion. OSA might be a risk factor for increased TSH even within reference range in hypertensive population. |
| format | Article |
| id | doaj-art-752d09f85263411f91a02bb500847264 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-752d09f85263411f91a02bb5008472642025-02-03T07:25:08ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/48027204802720Thyroid Stimulating Hormone Is Increased in Hypertensive Patients with Obstructive Sleep ApneaNanfang Li0Mulalibieke Heizhati1Chao Sun2Suofeiya Abulikemu3Liang Shao4Xiaoguang Yao5Yingchun Wang6Jing Hong7Ling Zhou8Lei Wang9Yu Zhang10Weiwei Zhang11The Center for Hypertension of the People’s Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, ChinaThe Center for Hypertension of the People’s Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, ChinaThe Center for Hypertension of the People’s Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, ChinaThe Center for Hypertension of the People’s Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, ChinaThe Center for Hypertension of the People’s Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, ChinaThe Center for Hypertension of the People’s Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, ChinaThe Center for Hypertension of the People’s Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, ChinaThe Center for Hypertension of the People’s Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, ChinaThe Center for Hypertension of the People’s Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, ChinaThe Center for Hypertension of the People’s Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, ChinaThe Center for Hypertension of the People’s Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, ChinaThe Center for Hypertension of the People’s Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, ChinaPurpose. To evaluate alteration in serum TSH in hypertensives with OSA and its relation with cardiometabolic risk factors. Methods. 517 hypertensives were cross-sectionally studied. OSA was determined by polysomnography and thyroid function by standard methods. Results. OSA was diagnosed in 373 hypertensives (72.15%). Prevalence of subclinical hypothyroidism was significantly higher in OSA hypertensives than in non-OSA ones (15.0% versus 6.9%, P=0.014). Serum LnTSH in hypertensives with severe OSA was significantly higher (0.99±0.81 versus 0.74±0.77 μIU/mL, P<0.05) than in those without OSA. AHI, LSaO2, ODI3, and ODI4 were independently associated with serum TSH for those aged 30–65 years. Dividing subjects into four groups as TSH < 1.0 μIU/mL, 1.0 ≤ THS ≤ 1.9 μIU/mL, 1.91 ≤ TSH < 4.5 μIU/mL, and TSH ≥ 4.5 μIU/mL, only 26.3% of OSA subjects exhibited TSH between 1.0 and 1.9 μIU/mL, significantly less than non-OSA subjects (26.3% versus 38.2%, P=0.01). DBP and serum LDL-c elevated with TSH increasing and were only significantly higher in TSH ≥ 4.5 μIU/mL group than in 1.0 ≤ TSH ≤ 1.9 μIU/mL group (96.32±14.19 versus 92.31±12.86 mmHg; P=0.040; 0.99±0.60 versus 0.87±0.34 mmol/L, P=0.023). Conclusion. OSA might be a risk factor for increased TSH even within reference range in hypertensive population.http://dx.doi.org/10.1155/2016/4802720 |
| spellingShingle | Nanfang Li Mulalibieke Heizhati Chao Sun Suofeiya Abulikemu Liang Shao Xiaoguang Yao Yingchun Wang Jing Hong Ling Zhou Lei Wang Yu Zhang Weiwei Zhang Thyroid Stimulating Hormone Is Increased in Hypertensive Patients with Obstructive Sleep Apnea International Journal of Endocrinology |
| title | Thyroid Stimulating Hormone Is Increased in Hypertensive Patients with Obstructive Sleep Apnea |
| title_full | Thyroid Stimulating Hormone Is Increased in Hypertensive Patients with Obstructive Sleep Apnea |
| title_fullStr | Thyroid Stimulating Hormone Is Increased in Hypertensive Patients with Obstructive Sleep Apnea |
| title_full_unstemmed | Thyroid Stimulating Hormone Is Increased in Hypertensive Patients with Obstructive Sleep Apnea |
| title_short | Thyroid Stimulating Hormone Is Increased in Hypertensive Patients with Obstructive Sleep Apnea |
| title_sort | thyroid stimulating hormone is increased in hypertensive patients with obstructive sleep apnea |
| url | http://dx.doi.org/10.1155/2016/4802720 |
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