Gastrointestinal Presentation of Eosinophilic Granulomatosis with Polyangiitis, Formerly Churg-Strauss Syndrome: A Case Report
Introduction: Some of the most common presentations of gastrointestinal diseases are nausea, vomiting, and generalized abdominal pain. These symptoms could also be associated with other diseases and require a structured approach to the specific diagnosis. Eosinophilic granulomatosis with...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2025-08-01
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| Series: | Case Reports in Gastroenterology |
| Online Access: | https://karger.com/article/doi/10.1159/000546038 |
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| author | Muhammad Umair Tayyub Arsh Gupta Rabia Ashraf Meenal Gupta Priyan Tantrige Howard Curtis Vinod Audimoolam |
| author_facet | Muhammad Umair Tayyub Arsh Gupta Rabia Ashraf Meenal Gupta Priyan Tantrige Howard Curtis Vinod Audimoolam |
| author_sort | Muhammad Umair Tayyub |
| collection | DOAJ |
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Introduction: Some of the most common presentations of gastrointestinal diseases are nausea, vomiting, and generalized abdominal pain. These symptoms could also be associated with other diseases and require a structured approach to the specific diagnosis. Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg-Strauss syndrome, is a small and medium-sized vessel vasculitis that can affect any body system and present with a wide range of symptoms and atypical presentation. Therefore, diagnosis of this condition may not always be straightforward. Case Presentation: This case report presents a challenging case of a young man presenting with symptoms of abdominal pain, nausea, vomiting and non-specific symptoms of lethargy and fatigue. The case describes overlapping features with granulomatosis with polyangiitis (GPA) and anti-neutrophil cytoplasmic antibodies (ANCA)-positive and -negative vasculitis. The patient needed extensive workup and investigations to be eventually diagnosed with EGPA. In this case, myeloperoxidase (MPO) ANCA was negative, which is positive in the majority of EGPA cases, and this poses an additional diagnostic dilemma. Conclusion: The case highlights that non-specific complaints of vomiting and abdominal pain should be addressed methodically and not just be treated symptomatically. |
| format | Article |
| id | doaj-art-752b7de2fb0a46b69f35f6d7ff21b57c |
| institution | DOAJ |
| issn | 1662-0631 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj-art-752b7de2fb0a46b69f35f6d7ff21b57c2025-08-20T02:58:16ZengKarger PublishersCase Reports in Gastroenterology1662-06312025-08-0119152753310.1159/000546038Gastrointestinal Presentation of Eosinophilic Granulomatosis with Polyangiitis, Formerly Churg-Strauss Syndrome: A Case ReportMuhammad Umair TayyubArsh GuptaRabia AshrafMeenal GuptaPriyan TantrigeHoward CurtisVinod Audimoolam Introduction: Some of the most common presentations of gastrointestinal diseases are nausea, vomiting, and generalized abdominal pain. These symptoms could also be associated with other diseases and require a structured approach to the specific diagnosis. Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg-Strauss syndrome, is a small and medium-sized vessel vasculitis that can affect any body system and present with a wide range of symptoms and atypical presentation. Therefore, diagnosis of this condition may not always be straightforward. Case Presentation: This case report presents a challenging case of a young man presenting with symptoms of abdominal pain, nausea, vomiting and non-specific symptoms of lethargy and fatigue. The case describes overlapping features with granulomatosis with polyangiitis (GPA) and anti-neutrophil cytoplasmic antibodies (ANCA)-positive and -negative vasculitis. The patient needed extensive workup and investigations to be eventually diagnosed with EGPA. In this case, myeloperoxidase (MPO) ANCA was negative, which is positive in the majority of EGPA cases, and this poses an additional diagnostic dilemma. Conclusion: The case highlights that non-specific complaints of vomiting and abdominal pain should be addressed methodically and not just be treated symptomatically. https://karger.com/article/doi/10.1159/000546038 |
| spellingShingle | Muhammad Umair Tayyub Arsh Gupta Rabia Ashraf Meenal Gupta Priyan Tantrige Howard Curtis Vinod Audimoolam Gastrointestinal Presentation of Eosinophilic Granulomatosis with Polyangiitis, Formerly Churg-Strauss Syndrome: A Case Report Case Reports in Gastroenterology |
| title | Gastrointestinal Presentation of Eosinophilic Granulomatosis with Polyangiitis, Formerly Churg-Strauss Syndrome: A Case Report |
| title_full | Gastrointestinal Presentation of Eosinophilic Granulomatosis with Polyangiitis, Formerly Churg-Strauss Syndrome: A Case Report |
| title_fullStr | Gastrointestinal Presentation of Eosinophilic Granulomatosis with Polyangiitis, Formerly Churg-Strauss Syndrome: A Case Report |
| title_full_unstemmed | Gastrointestinal Presentation of Eosinophilic Granulomatosis with Polyangiitis, Formerly Churg-Strauss Syndrome: A Case Report |
| title_short | Gastrointestinal Presentation of Eosinophilic Granulomatosis with Polyangiitis, Formerly Churg-Strauss Syndrome: A Case Report |
| title_sort | gastrointestinal presentation of eosinophilic granulomatosis with polyangiitis formerly churg strauss syndrome a case report |
| url | https://karger.com/article/doi/10.1159/000546038 |
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