Female germline stem cells: recent advances, opportunities, and challenges to overcome
Abstract In the field of reproductive medicine, delaying ovarian aging and preserving fertility in cancer patients have long been core issues and relentless pursuits. Female germline stem cells (FGSCs) have been shown to repair aging or damaged ovarian structures and to restore ovarian reproductive...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-08-01
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| Series: | Cell Regeneration |
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| Online Access: | https://doi.org/10.1186/s13619-025-00256-8 |
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| author | Yaoqi Huang Haifeng Ye |
| author_facet | Yaoqi Huang Haifeng Ye |
| author_sort | Yaoqi Huang |
| collection | DOAJ |
| description | Abstract In the field of reproductive medicine, delaying ovarian aging and preserving fertility in cancer patients have long been core issues and relentless pursuits. Female germline stem cells (FGSCs) have been shown to repair aging or damaged ovarian structures and to restore ovarian reproductive and endocrine function. With their unlimited proliferation and directed differentiation into oocytes, FGSCs bring new hope to patients with ovarian insufficiency, malignant tumors, and others needing fertility preservation. In this review, we introduce the role of FGSCs in ovarian fertility preservation and regenerative repair, emphasizing the regulatory pathways of FGSCs in restoring ovarian function. We discuss the unique advantages of FGSCs in infertility treatment, including fertility preservation, animal gene editing, and regenerative medicine. This article aims to offer new research insights for advancing the clinical translation of FGSCs by exploring them from multiple perspectives, such as origin, regulation, and application. |
| format | Article |
| id | doaj-art-752a9e75690c49f4a4d05b0abaf0ff55 |
| institution | DOAJ |
| issn | 2045-9769 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Cell Regeneration |
| spelling | doaj-art-752a9e75690c49f4a4d05b0abaf0ff552025-08-20T03:05:13ZengSpringerOpenCell Regeneration2045-97692025-08-0114111310.1186/s13619-025-00256-8Female germline stem cells: recent advances, opportunities, and challenges to overcomeYaoqi Huang0Haifeng Ye1Medical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital; School of Basic Medical Sciences; Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang UniversityMedical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital; School of Basic Medical Sciences; Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang UniversityAbstract In the field of reproductive medicine, delaying ovarian aging and preserving fertility in cancer patients have long been core issues and relentless pursuits. Female germline stem cells (FGSCs) have been shown to repair aging or damaged ovarian structures and to restore ovarian reproductive and endocrine function. With their unlimited proliferation and directed differentiation into oocytes, FGSCs bring new hope to patients with ovarian insufficiency, malignant tumors, and others needing fertility preservation. In this review, we introduce the role of FGSCs in ovarian fertility preservation and regenerative repair, emphasizing the regulatory pathways of FGSCs in restoring ovarian function. We discuss the unique advantages of FGSCs in infertility treatment, including fertility preservation, animal gene editing, and regenerative medicine. This article aims to offer new research insights for advancing the clinical translation of FGSCs by exploring them from multiple perspectives, such as origin, regulation, and application.https://doi.org/10.1186/s13619-025-00256-8Female germline stem cellsPremature ovarian insufficiencyArtificial ovaryOvarian repair |
| spellingShingle | Yaoqi Huang Haifeng Ye Female germline stem cells: recent advances, opportunities, and challenges to overcome Cell Regeneration Female germline stem cells Premature ovarian insufficiency Artificial ovary Ovarian repair |
| title | Female germline stem cells: recent advances, opportunities, and challenges to overcome |
| title_full | Female germline stem cells: recent advances, opportunities, and challenges to overcome |
| title_fullStr | Female germline stem cells: recent advances, opportunities, and challenges to overcome |
| title_full_unstemmed | Female germline stem cells: recent advances, opportunities, and challenges to overcome |
| title_short | Female germline stem cells: recent advances, opportunities, and challenges to overcome |
| title_sort | female germline stem cells recent advances opportunities and challenges to overcome |
| topic | Female germline stem cells Premature ovarian insufficiency Artificial ovary Ovarian repair |
| url | https://doi.org/10.1186/s13619-025-00256-8 |
| work_keys_str_mv | AT yaoqihuang femalegermlinestemcellsrecentadvancesopportunitiesandchallengestoovercome AT haifengye femalegermlinestemcellsrecentadvancesopportunitiesandchallengestoovercome |