Management strategies following implantation failure of euploid embryos
Abstract Background Euploid blastocyst implantation failure may result from embryonic factors undetectable by preimplantation genetic testing for aneuploidy (PGT‐A); however, various nonembryonic factors can also intricately interfere with implantation. This review seeks to clarify evidence‐based te...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Reproductive Medicine and Biology |
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| Online Access: | https://doi.org/10.1002/rmb2.12576 |
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| author | Keiji Kuroda |
| author_facet | Keiji Kuroda |
| author_sort | Keiji Kuroda |
| collection | DOAJ |
| description | Abstract Background Euploid blastocyst implantation failure may result from embryonic factors undetectable by preimplantation genetic testing for aneuploidy (PGT‐A); however, various nonembryonic factors can also intricately interfere with implantation. This review seeks to clarify evidence‐based testing and treatments for implantation failure after euploid embryo transfer. Methods We conducted a review of the literature on implantation failure after euploid embryo transfer or multiple embryo transfer cycles, which mainly included systematic reviews and meta‐analyses. Results The recommended tests for implantation failure include (1) hysteroscopy, (2) endometrial CD138 immunohistochemistry and bacterial culture, (3) serum 25‐hydroxyvitamin D3, and (4) thrombophilia screening. Based on diagnostic findings, the following treatments have been recommended: (1) antibiotics for chronic endometritis, (2) vitamin D replacement, (3) lifestyle modification, and (4) low‐dose aspirin starting from the postimplantation period for thrombophilia. Moreover, frozen–thawed single euploid blastocyst transfer using assisted hatching and hyaluronan‐enriched transfer medium may support embryo implantation. Conclusion To ensure a successful pregnancy in subsequent embryo transfers, simple, inexpensive, and evidence‐based tests and treatments should be selected. |
| format | Article |
| id | doaj-art-7527c1b5cfdf461582123fac9d3ec00b |
| institution | DOAJ |
| issn | 1445-5781 1447-0578 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Reproductive Medicine and Biology |
| spelling | doaj-art-7527c1b5cfdf461582123fac9d3ec00b2025-08-20T02:52:37ZengWileyReproductive Medicine and Biology1445-57811447-05782024-01-01231n/an/a10.1002/rmb2.12576Management strategies following implantation failure of euploid embryosKeiji Kuroda0Center for Reproductive Medicine and Endoscopy Sugiyama Clinic Marunouchi Tokyo JapanAbstract Background Euploid blastocyst implantation failure may result from embryonic factors undetectable by preimplantation genetic testing for aneuploidy (PGT‐A); however, various nonembryonic factors can also intricately interfere with implantation. This review seeks to clarify evidence‐based testing and treatments for implantation failure after euploid embryo transfer. Methods We conducted a review of the literature on implantation failure after euploid embryo transfer or multiple embryo transfer cycles, which mainly included systematic reviews and meta‐analyses. Results The recommended tests for implantation failure include (1) hysteroscopy, (2) endometrial CD138 immunohistochemistry and bacterial culture, (3) serum 25‐hydroxyvitamin D3, and (4) thrombophilia screening. Based on diagnostic findings, the following treatments have been recommended: (1) antibiotics for chronic endometritis, (2) vitamin D replacement, (3) lifestyle modification, and (4) low‐dose aspirin starting from the postimplantation period for thrombophilia. Moreover, frozen–thawed single euploid blastocyst transfer using assisted hatching and hyaluronan‐enriched transfer medium may support embryo implantation. Conclusion To ensure a successful pregnancy in subsequent embryo transfers, simple, inexpensive, and evidence‐based tests and treatments should be selected.https://doi.org/10.1002/rmb2.12576euploid embryoimplantation failurein vitro fertilizationinfertilitypreimplantation genetic testing |
| spellingShingle | Keiji Kuroda Management strategies following implantation failure of euploid embryos Reproductive Medicine and Biology euploid embryo implantation failure in vitro fertilization infertility preimplantation genetic testing |
| title | Management strategies following implantation failure of euploid embryos |
| title_full | Management strategies following implantation failure of euploid embryos |
| title_fullStr | Management strategies following implantation failure of euploid embryos |
| title_full_unstemmed | Management strategies following implantation failure of euploid embryos |
| title_short | Management strategies following implantation failure of euploid embryos |
| title_sort | management strategies following implantation failure of euploid embryos |
| topic | euploid embryo implantation failure in vitro fertilization infertility preimplantation genetic testing |
| url | https://doi.org/10.1002/rmb2.12576 |
| work_keys_str_mv | AT keijikuroda managementstrategiesfollowingimplantationfailureofeuploidembryos |