Neurological Manifestations of Patients With CNS Metastases: Experience From a Single Center in an Upper-Middle-Income Country
PURPOSEThis study aimed to report the neurological manifestations of patients with CNS metastases (CNSm) and to determine their association with survival in patients with brain metastases (BrMs).MATERIALS AND METHODSA retrospective analysis of patients with CNSms (BrMs or neoplastic meningitis) seen...
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American Society of Clinical Oncology
2025-04-01
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| Series: | JCO Global Oncology |
| Online Access: | https://ascopubs.org/doi/10.1200/GO-24-00465 |
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| author | Bernardo Cacho-Díaz Alberto González-Aguilar Gervith Reyes-Soto José O. Navarro-Fernández Federico Maldonado-Magos Oscar Arrieta Talia Wegman-Ostrosky Orwa Aboud Mónica Serrano-Murillo |
| author_facet | Bernardo Cacho-Díaz Alberto González-Aguilar Gervith Reyes-Soto José O. Navarro-Fernández Federico Maldonado-Magos Oscar Arrieta Talia Wegman-Ostrosky Orwa Aboud Mónica Serrano-Murillo |
| author_sort | Bernardo Cacho-Díaz |
| collection | DOAJ |
| description | PURPOSEThis study aimed to report the neurological manifestations of patients with CNS metastases (CNSm) and to determine their association with survival in patients with brain metastases (BrMs).MATERIALS AND METHODSA retrospective analysis of patients with CNSms (BrMs or neoplastic meningitis) seen at two referral centers between 2010 and 2022. The neurological manifestations and their association with survival were measured and presented.RESULTSAmong 822 patients with CNSms, the most common neurological manifestations were headache, focal weakness, visual disorders, nausea/vomiting, seizures, and altered mental status (53%, 35%, 24%, 23%, 22%, and 18%, respectively). In patients with BrMs, neurological manifestations associated with survival were asymptomatic (hazard ratio [HR], 0.48 [95% CI, 0.31 to 0.73]; P = .001), focal weakness (HR, 1.26 [95% CI, 1.02 to 1.54]; P = .027), or visual disorders (HR, 1.26 [95% CI, 1.01 to 1.58]; P = .045).CONCLUSIONNeurological manifestations in patients with BrMs are associated with survival and can aid in prognostic stratification. |
| format | Article |
| id | doaj-art-75249d78f64e4719881089ad084e94dd |
| institution | OA Journals |
| issn | 2687-8941 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | American Society of Clinical Oncology |
| record_format | Article |
| series | JCO Global Oncology |
| spelling | doaj-art-75249d78f64e4719881089ad084e94dd2025-08-20T02:24:59ZengAmerican Society of Clinical OncologyJCO Global Oncology2687-89412025-04-011110.1200/GO-24-00465Neurological Manifestations of Patients With CNS Metastases: Experience From a Single Center in an Upper-Middle-Income CountryBernardo Cacho-Díaz0Alberto González-Aguilar1Gervith Reyes-Soto2José O. Navarro-Fernández3Federico Maldonado-Magos4Oscar Arrieta5Talia Wegman-Ostrosky6Orwa Aboud7Mónica Serrano-Murillo8Unidad de Neuro-Oncología, Instituto Nacional de Cancerología, Mexico City, MexicoNeuro-Oncology Unit, Instituto Nacional de Neurología y Neurocirugía, México City, MexicoUnidad de Neuro-Oncología, Instituto Nacional de Cancerología, Mexico City, MexicoUnidad de Neuro-Oncología, Instituto Nacional de Cancerología, Mexico City, MexicoSubdirección de Radioterapia, Instituto Nacional de Cancerología, México City, MexicoThoracic Oncology Unit, Instituto Nacional de Cancerología, México City, MexicoResearch Unit, Instituto Nacional de Cancerología, México City, MexicoDepartment of Neurology, Neurological Surgery, and Comprehensive Cancer Center, University of California, Davis, Sacramento, CAUnidad de Neuro-Oncología, Instituto Nacional de Cancerología, México City, MéxicoPURPOSEThis study aimed to report the neurological manifestations of patients with CNS metastases (CNSm) and to determine their association with survival in patients with brain metastases (BrMs).MATERIALS AND METHODSA retrospective analysis of patients with CNSms (BrMs or neoplastic meningitis) seen at two referral centers between 2010 and 2022. The neurological manifestations and their association with survival were measured and presented.RESULTSAmong 822 patients with CNSms, the most common neurological manifestations were headache, focal weakness, visual disorders, nausea/vomiting, seizures, and altered mental status (53%, 35%, 24%, 23%, 22%, and 18%, respectively). In patients with BrMs, neurological manifestations associated with survival were asymptomatic (hazard ratio [HR], 0.48 [95% CI, 0.31 to 0.73]; P = .001), focal weakness (HR, 1.26 [95% CI, 1.02 to 1.54]; P = .027), or visual disorders (HR, 1.26 [95% CI, 1.01 to 1.58]; P = .045).CONCLUSIONNeurological manifestations in patients with BrMs are associated with survival and can aid in prognostic stratification.https://ascopubs.org/doi/10.1200/GO-24-00465 |
| spellingShingle | Bernardo Cacho-Díaz Alberto González-Aguilar Gervith Reyes-Soto José O. Navarro-Fernández Federico Maldonado-Magos Oscar Arrieta Talia Wegman-Ostrosky Orwa Aboud Mónica Serrano-Murillo Neurological Manifestations of Patients With CNS Metastases: Experience From a Single Center in an Upper-Middle-Income Country JCO Global Oncology |
| title | Neurological Manifestations of Patients With CNS Metastases: Experience From a Single Center in an Upper-Middle-Income Country |
| title_full | Neurological Manifestations of Patients With CNS Metastases: Experience From a Single Center in an Upper-Middle-Income Country |
| title_fullStr | Neurological Manifestations of Patients With CNS Metastases: Experience From a Single Center in an Upper-Middle-Income Country |
| title_full_unstemmed | Neurological Manifestations of Patients With CNS Metastases: Experience From a Single Center in an Upper-Middle-Income Country |
| title_short | Neurological Manifestations of Patients With CNS Metastases: Experience From a Single Center in an Upper-Middle-Income Country |
| title_sort | neurological manifestations of patients with cns metastases experience from a single center in an upper middle income country |
| url | https://ascopubs.org/doi/10.1200/GO-24-00465 |
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