ERK1/2 Inhibition Alleviates Diabetic Cardiomyopathy by Suppressing Fatty Acid Metabolism

ERK1/2 Inhibition Alleviates Diabetic Cardiomyopathy by Suppressing Fatty Acid Metabolism

Background: Diabetes mellitus is associated with morphological and functional impairment of the heart primarily due to lipid toxicity caused by increased fatty acid metabolism. Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) have been implicated in the metabolism o...

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Bibliographic Details
Main Authors: Erin McLean, Caroline De Roo, Annabel Maag, Megan Coble, Jefferson Cano, Ruijie Liu
Format: Article
Language:English
Published: IMR Press 2025-01-01
Series:Frontiers in Bioscience-Landmark
Subjects:
cardiac remodeling
diabetes mellitus
erk1/2
fatty acid metabolism
Online Access:https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL26700
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