LncRNAs in oncogenic microenvironment: from threat to therapy
LncRNAs are RNA molecules of more than 200 nucleotides in length and participate in cellular metabolism and cellular responses through their diverse interactomedespite having no protein-coding capabilities. Such significant interactions also implicate the presence of lncRNAs in complex pathobiologic...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1423279/full |
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| author | Dipanjan Roy Bireswar Bhattacharya Rudra Chakravarti Prabhjot Singh Mansi Arya Anirban Kundu Ajay Patil Bhukiya Siva Sunny Mehta Tawsif Ahmed Kazi Dipanjan Ghosh |
| author_facet | Dipanjan Roy Bireswar Bhattacharya Rudra Chakravarti Prabhjot Singh Mansi Arya Anirban Kundu Ajay Patil Bhukiya Siva Sunny Mehta Tawsif Ahmed Kazi Dipanjan Ghosh |
| author_sort | Dipanjan Roy |
| collection | DOAJ |
| description | LncRNAs are RNA molecules of more than 200 nucleotides in length and participate in cellular metabolism and cellular responses through their diverse interactomedespite having no protein-coding capabilities. Such significant interactions also implicate the presence of lncRNAs in complex pathobiological pathways of various diseases, affecting cellular survival by modulating autophagy, inflammation and apoptosis. Proliferating cells harbour a complex microenvironment that mainly stimulate growth-specific activities such as DNA replication, repair, and protein synthesis. They also recognise damages at the macromolecular level, preventing them from reaching the next-generation. LncRNAs have shown significant association with the events occurring towards proliferation, regulating key events in dividing cells, and dysregulation of lncRNA transcriptome affects normal cellular life-cycle, promoting the development of cancer. Furthermore, lncRNAs also demonstrated an association with cancer growth and progression by regulating key pathways governing cell growth, epithelial-mesenchymal transition and metastasis. This makes lncRNAs an attractive target for the treatment of cancer and can also be used as a marker for the diagnosis and prognosis of diseases due to their differential expression in diseased samples. This review delves into the correlation of the lncRNA transcriptome with the fundamental cellular signalling and how this crosstalk shapes the complexity of the oncogenic microhabitat. |
| format | Article |
| id | doaj-art-751d621e90cb44088800dcf0690763d1 |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-751d621e90cb44088800dcf0690763d12025-08-20T02:51:53ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-03-011210.3389/fcell.2024.14232791423279LncRNAs in oncogenic microenvironment: from threat to therapyDipanjan RoyBireswar BhattacharyaRudra ChakravartiPrabhjot SinghMansi AryaAnirban KunduAjay PatilBhukiya SivaSunny MehtaTawsif Ahmed KaziDipanjan GhoshLncRNAs are RNA molecules of more than 200 nucleotides in length and participate in cellular metabolism and cellular responses through their diverse interactomedespite having no protein-coding capabilities. Such significant interactions also implicate the presence of lncRNAs in complex pathobiological pathways of various diseases, affecting cellular survival by modulating autophagy, inflammation and apoptosis. Proliferating cells harbour a complex microenvironment that mainly stimulate growth-specific activities such as DNA replication, repair, and protein synthesis. They also recognise damages at the macromolecular level, preventing them from reaching the next-generation. LncRNAs have shown significant association with the events occurring towards proliferation, regulating key events in dividing cells, and dysregulation of lncRNA transcriptome affects normal cellular life-cycle, promoting the development of cancer. Furthermore, lncRNAs also demonstrated an association with cancer growth and progression by regulating key pathways governing cell growth, epithelial-mesenchymal transition and metastasis. This makes lncRNAs an attractive target for the treatment of cancer and can also be used as a marker for the diagnosis and prognosis of diseases due to their differential expression in diseased samples. This review delves into the correlation of the lncRNA transcriptome with the fundamental cellular signalling and how this crosstalk shapes the complexity of the oncogenic microhabitat.https://www.frontiersin.org/articles/10.3389/fcell.2024.1423279/fulllncRNAcancertumor microenvironmentcancer therapyinflammationapoptosis |
| spellingShingle | Dipanjan Roy Bireswar Bhattacharya Rudra Chakravarti Prabhjot Singh Mansi Arya Anirban Kundu Ajay Patil Bhukiya Siva Sunny Mehta Tawsif Ahmed Kazi Dipanjan Ghosh LncRNAs in oncogenic microenvironment: from threat to therapy Frontiers in Cell and Developmental Biology lncRNA cancer tumor microenvironment cancer therapy inflammation apoptosis |
| title | LncRNAs in oncogenic microenvironment: from threat to therapy |
| title_full | LncRNAs in oncogenic microenvironment: from threat to therapy |
| title_fullStr | LncRNAs in oncogenic microenvironment: from threat to therapy |
| title_full_unstemmed | LncRNAs in oncogenic microenvironment: from threat to therapy |
| title_short | LncRNAs in oncogenic microenvironment: from threat to therapy |
| title_sort | lncrnas in oncogenic microenvironment from threat to therapy |
| topic | lncRNA cancer tumor microenvironment cancer therapy inflammation apoptosis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1423279/full |
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