Unveiling the Solvent Effect: DMSO Interaction with Human Nerve Growth Factor and Its Implications for Drug Discovery

Unveiling the Solvent Effect: DMSO Interaction with Human Nerve Growth Factor and Its Implications for Drug Discovery

<b>Background:</b> The Nerve Growth Factor (NGF) is essential for neuronal survival and function and represents a key therapeutic target for pain and inflammation-related disorders, as well as for neurodegenerative diseases. Small-molecule antagonists of human NGF (hNGF) offer advantages...

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Bibliographic Details
Main Authors: Francesca Paoletti, Tjaša Goričan, Alberto Cassetta, Jože Grdadolnik, Mykola Toporash, Doriano Lamba, Simona Golič Grdadolnik, Sonia Covaceuszach
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
Nerve Growth Factor (NGF)
dimethyl sulfoxide (DMSO)
drug discovery
Nuclear Magnetic Resonance (NMR)
Fourier Transform Infrared (FT-IR) spectroscopy
Differential Scanning Fluorimetry (DSF)
Online Access:https://www.mdpi.com/1420-3049/30/14/3030
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