Case report: Detecting giant cell arteritis in [68Ga]Ga-DOTA-Siglec-9-PET/CT
ObjectivesThis study aimed to evaluate the diagnostic utility of [68Ga]Ga-DOTA-Siglec-9 positron emission tomography-computed tomography (PET/CT) in assessing disease activity in a patient experiencing a relapse of giant cell arteritis (GCA).Case presentationA 90-year-old male patient with GCA, diag...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1501790/full |
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| author | Simon M. Petzinna Jim Küppers Benedikt Schemmer Anna L. Kernder Anna L. Kernder Claus-Jürgen Bauer Leon von der Emde Babak Salam Jörg H. W. Distler Anja Winklbauer Markus Essler Valentin S. Schäfer |
| author_facet | Simon M. Petzinna Jim Küppers Benedikt Schemmer Anna L. Kernder Anna L. Kernder Claus-Jürgen Bauer Leon von der Emde Babak Salam Jörg H. W. Distler Anja Winklbauer Markus Essler Valentin S. Schäfer |
| author_sort | Simon M. Petzinna |
| collection | DOAJ |
| description | ObjectivesThis study aimed to evaluate the diagnostic utility of [68Ga]Ga-DOTA-Siglec-9 positron emission tomography-computed tomography (PET/CT) in assessing disease activity in a patient experiencing a relapse of giant cell arteritis (GCA).Case presentationA 90-year-old male patient with GCA, diagnosed in 2018, was enrolled. Demographic data, disease history, and laboratory parameters, including soluble VAP-1 (sVAP-1) levels, were recorded. The patient underwent a [68Ga]Ga-DOTA-Siglec-9 PET/CT scan. Additional imaging assessments included vascular ultrasound of the superficial temporal arteries, their branches, and the facial, axillary, subclavian, carotid, and vertebral arteries, along with magnetic resonance imaging (MRI) of the aorta.The patient’s sVAP-1 level was 284 ng/ml compared to 123 ng/ml in the control group (SD ± 55). The [68Ga]Ga-DOTA-Siglec-9 PET/CT scan revealed increased tracer uptake (SUVmax) in the subclavian artery (2.5), aortic arch (2.9), and heart (2.9). Notably, the increased uptake in the descending aorta (3.5) abruptly diminished to 2.2 when passing the diaphragm, with no changes in vessel caliber observed in CT. The injection of [68Ga]Ga-DOTA-Siglec-9 was well tolerated. Aortic MRI revealed no signs of inflammatory involvement.ConclusionsThis study introduces the first application of [68Ga]Ga-DOTA-Siglec-9 PET/CT in a patient with GCA experiencing a relapse, revealing enhanced tracer uptake in the subclavian artery and aortic arch with a localized and abrupt reduction, absent in conventional imaging. These findings suggest that [68Ga]Ga-DOTA-Siglec-9 PET/CT has significant potential for precise, inflammation-specific detection of affected vascular tissue in GCA during relapse. |
| format | Article |
| id | doaj-art-751b26b7556d48cca2f9673e10893f3b |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-751b26b7556d48cca2f9673e10893f3b2025-01-03T08:57:16ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.15017901501790Case report: Detecting giant cell arteritis in [68Ga]Ga-DOTA-Siglec-9-PET/CTSimon M. Petzinna0Jim Küppers1Benedikt Schemmer2Anna L. Kernder3Anna L. Kernder4Claus-Jürgen Bauer5Leon von der Emde6Babak Salam7Jörg H. W. Distler8Anja Winklbauer9Markus Essler10Valentin S. Schäfer11Department of Rheumatology and Clinical Immunology, Clinic of Internal Medicine III, University Hospital Bonn, Bonn, GermanyDepartment of Nuclear Medicine, University Hospital Bonn, Bonn, GermanyDepartment of Nuclear Medicine, University Hospital Bonn, Bonn, GermanyClinic for Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine-University, Düsseldorf, GermanyHiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine-University, Düsseldorf, GermanyDepartment of Rheumatology and Clinical Immunology, Clinic of Internal Medicine III, University Hospital Bonn, Bonn, GermanyDepartment of Ophthalmology, University Hospital Bonn, Bonn, GermanyDepartment of Radiology, University Hospital Bonn, Bonn, GermanyClinic for Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine-University, Düsseldorf, GermanyDepartment of Rheumatology and Clinical Immunology, Clinic of Internal Medicine III, University Hospital Bonn, Bonn, GermanyDepartment of Nuclear Medicine, University Hospital Bonn, Bonn, GermanyDepartment of Rheumatology and Clinical Immunology, Clinic of Internal Medicine III, University Hospital Bonn, Bonn, GermanyObjectivesThis study aimed to evaluate the diagnostic utility of [68Ga]Ga-DOTA-Siglec-9 positron emission tomography-computed tomography (PET/CT) in assessing disease activity in a patient experiencing a relapse of giant cell arteritis (GCA).Case presentationA 90-year-old male patient with GCA, diagnosed in 2018, was enrolled. Demographic data, disease history, and laboratory parameters, including soluble VAP-1 (sVAP-1) levels, were recorded. The patient underwent a [68Ga]Ga-DOTA-Siglec-9 PET/CT scan. Additional imaging assessments included vascular ultrasound of the superficial temporal arteries, their branches, and the facial, axillary, subclavian, carotid, and vertebral arteries, along with magnetic resonance imaging (MRI) of the aorta.The patient’s sVAP-1 level was 284 ng/ml compared to 123 ng/ml in the control group (SD ± 55). The [68Ga]Ga-DOTA-Siglec-9 PET/CT scan revealed increased tracer uptake (SUVmax) in the subclavian artery (2.5), aortic arch (2.9), and heart (2.9). Notably, the increased uptake in the descending aorta (3.5) abruptly diminished to 2.2 when passing the diaphragm, with no changes in vessel caliber observed in CT. The injection of [68Ga]Ga-DOTA-Siglec-9 was well tolerated. Aortic MRI revealed no signs of inflammatory involvement.ConclusionsThis study introduces the first application of [68Ga]Ga-DOTA-Siglec-9 PET/CT in a patient with GCA experiencing a relapse, revealing enhanced tracer uptake in the subclavian artery and aortic arch with a localized and abrupt reduction, absent in conventional imaging. These findings suggest that [68Ga]Ga-DOTA-Siglec-9 PET/CT has significant potential for precise, inflammation-specific detection of affected vascular tissue in GCA during relapse.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1501790/fullgiant cell arteritisvasculitisinflammationimagingbiomarkerpositron emission tomography-computed tomography |
| spellingShingle | Simon M. Petzinna Jim Küppers Benedikt Schemmer Anna L. Kernder Anna L. Kernder Claus-Jürgen Bauer Leon von der Emde Babak Salam Jörg H. W. Distler Anja Winklbauer Markus Essler Valentin S. Schäfer Case report: Detecting giant cell arteritis in [68Ga]Ga-DOTA-Siglec-9-PET/CT Frontiers in Immunology giant cell arteritis vasculitis inflammation imaging biomarker positron emission tomography-computed tomography |
| title | Case report: Detecting giant cell arteritis in [68Ga]Ga-DOTA-Siglec-9-PET/CT |
| title_full | Case report: Detecting giant cell arteritis in [68Ga]Ga-DOTA-Siglec-9-PET/CT |
| title_fullStr | Case report: Detecting giant cell arteritis in [68Ga]Ga-DOTA-Siglec-9-PET/CT |
| title_full_unstemmed | Case report: Detecting giant cell arteritis in [68Ga]Ga-DOTA-Siglec-9-PET/CT |
| title_short | Case report: Detecting giant cell arteritis in [68Ga]Ga-DOTA-Siglec-9-PET/CT |
| title_sort | case report detecting giant cell arteritis in 68ga ga dota siglec 9 pet ct |
| topic | giant cell arteritis vasculitis inflammation imaging biomarker positron emission tomography-computed tomography |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1501790/full |
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