The Molecular Basis of Amino Acids Sensing
Abstract Amino acids are organic compounds that serve as the building blocks of proteins and peptides. Additionally, they function as bioactive molecules that play important roles in metabolic regulation and signal transduction. The ability of cells to sense fluctuations in intracellular and extrace...
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| Format: | Article |
| Language: | English |
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Wiley
2025-07-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202501889 |
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| author | Cong Jiang Xiao Tan Jiali Jin Ping Wang |
| author_facet | Cong Jiang Xiao Tan Jiali Jin Ping Wang |
| author_sort | Cong Jiang |
| collection | DOAJ |
| description | Abstract Amino acids are organic compounds that serve as the building blocks of proteins and peptides. Additionally, they function as bioactive molecules that play important roles in metabolic regulation and signal transduction. The ability of cells to sense fluctuations in intracellular and extracellular amino acid levels is vital for effectively regulating protein synthesis and catabolism, maintaining homeostasis, adapting to diverse nutritional environments and influencing cell fate decision. In this review, the recent molecular insights into amino acids sensing are discussed, along with the different sensing mechanisms in distinct organisms. |
| format | Article |
| id | doaj-art-7518c95fb11a46a8b940c732a516bfcd |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-7518c95fb11a46a8b940c732a516bfcd2025-08-20T03:04:57ZengWileyAdvanced Science2198-38442025-07-011226n/an/a10.1002/advs.202501889The Molecular Basis of Amino Acids SensingCong Jiang0Xiao Tan1Jiali Jin2Ping Wang3Shanghai Tenth People's Hospital School of Medicine Tongji University Cancer Center Tongji University Shanghai 200092 ChinaShanghai Tenth People's Hospital School of Medicine Tongji University Cancer Center Tongji University Shanghai 200092 ChinaShanghai Tenth People's Hospital School of Medicine Tongji University Cancer Center Tongji University Shanghai 200092 ChinaShanghai Tenth People's Hospital School of Medicine Tongji University Cancer Center Tongji University Shanghai 200092 ChinaAbstract Amino acids are organic compounds that serve as the building blocks of proteins and peptides. Additionally, they function as bioactive molecules that play important roles in metabolic regulation and signal transduction. The ability of cells to sense fluctuations in intracellular and extracellular amino acid levels is vital for effectively regulating protein synthesis and catabolism, maintaining homeostasis, adapting to diverse nutritional environments and influencing cell fate decision. In this review, the recent molecular insights into amino acids sensing are discussed, along with the different sensing mechanisms in distinct organisms.https://doi.org/10.1002/advs.202501889amino acid sensingamino acid sensornutrient stressmTORC1 |
| spellingShingle | Cong Jiang Xiao Tan Jiali Jin Ping Wang The Molecular Basis of Amino Acids Sensing Advanced Science amino acid sensing amino acid sensor nutrient stress mTORC1 |
| title | The Molecular Basis of Amino Acids Sensing |
| title_full | The Molecular Basis of Amino Acids Sensing |
| title_fullStr | The Molecular Basis of Amino Acids Sensing |
| title_full_unstemmed | The Molecular Basis of Amino Acids Sensing |
| title_short | The Molecular Basis of Amino Acids Sensing |
| title_sort | molecular basis of amino acids sensing |
| topic | amino acid sensing amino acid sensor nutrient stress mTORC1 |
| url | https://doi.org/10.1002/advs.202501889 |
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