Insights of immune cell heterogeneity, tumor-initiated subtype transformation, drug resistance, treatment and detecting technologies in glioma microenvironment
Background: With the gradual understanding of glioma development and the immune microenvironment, many immune cells have been discovered. Despite the growing comprehension of immune cell functions and the clinical application of immunotherapy, the precise roles and characteristics of immune cell sub...
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Elsevier
2025-06-01
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| Series: | Journal of Advanced Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123224003151 |
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| author | Tongzheng Chen Wenbin Ma Xin Wang Qile Ye Xintong Hou Yiwei Wang Chuanlu Jiang Xiangqi Meng Ying Sun Jinquan Cai |
| author_facet | Tongzheng Chen Wenbin Ma Xin Wang Qile Ye Xintong Hou Yiwei Wang Chuanlu Jiang Xiangqi Meng Ying Sun Jinquan Cai |
| author_sort | Tongzheng Chen |
| collection | DOAJ |
| description | Background: With the gradual understanding of glioma development and the immune microenvironment, many immune cells have been discovered. Despite the growing comprehension of immune cell functions and the clinical application of immunotherapy, the precise roles and characteristics of immune cell subtypes, how glioma induces subtype transformation of immune cells and its impact on glioma progression have yet to be understood. Aim of the review: In this review, we comprehensively center on the four major immune cells within the glioma microenvironment, particularly neutrophils, macrophages, lymphocytes, myeloid-derived suppressor cells (MDSCs), and other significant immune cells. We discuss (1) immune cell subtype markers, (2) glioma-induced immune cell subtype transformation, (3) the mechanisms of each subtype influencing chemotherapy resistance, (4) therapies targeting immune cells, and (5) immune cell-associated single-cell sequencing. Eventually, we identified the characteristics of immune cell subtypes in glioma, comprehensively summarized the exact mechanism of glioma-induced immune cell subtype transformation, and concluded the progress of single-cell sequencing in exploring immune cell subtypes in glioma. Key scientific concepts of review: In conclusion, we have analyzed the mechanism of chemotherapy resistance detailly, and have discovered prospective immunotherapy targets, excavating the potential of novel immunotherapies approach that synergistically combines radiotherapy, chemotherapy, and surgery, thereby paving the way for improved immunotherapeutic strategies against glioma and enhanced patient outcomes. |
| format | Article |
| id | doaj-art-7515edefdced4c67a01592067e573586 |
| institution | DOAJ |
| issn | 2090-1232 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj-art-7515edefdced4c67a01592067e5735862025-08-20T03:08:17ZengElsevierJournal of Advanced Research2090-12322025-06-017252755410.1016/j.jare.2024.07.033Insights of immune cell heterogeneity, tumor-initiated subtype transformation, drug resistance, treatment and detecting technologies in glioma microenvironmentTongzheng Chen0Wenbin Ma1Xin Wang2Qile Ye3Xintong Hou4Yiwei Wang5Chuanlu Jiang6Xiangqi Meng7Ying Sun8Jinquan Cai9Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; The Six Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; Corresponding authors.Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; Corresponding authors.Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; Corresponding authors.Background: With the gradual understanding of glioma development and the immune microenvironment, many immune cells have been discovered. Despite the growing comprehension of immune cell functions and the clinical application of immunotherapy, the precise roles and characteristics of immune cell subtypes, how glioma induces subtype transformation of immune cells and its impact on glioma progression have yet to be understood. Aim of the review: In this review, we comprehensively center on the four major immune cells within the glioma microenvironment, particularly neutrophils, macrophages, lymphocytes, myeloid-derived suppressor cells (MDSCs), and other significant immune cells. We discuss (1) immune cell subtype markers, (2) glioma-induced immune cell subtype transformation, (3) the mechanisms of each subtype influencing chemotherapy resistance, (4) therapies targeting immune cells, and (5) immune cell-associated single-cell sequencing. Eventually, we identified the characteristics of immune cell subtypes in glioma, comprehensively summarized the exact mechanism of glioma-induced immune cell subtype transformation, and concluded the progress of single-cell sequencing in exploring immune cell subtypes in glioma. Key scientific concepts of review: In conclusion, we have analyzed the mechanism of chemotherapy resistance detailly, and have discovered prospective immunotherapy targets, excavating the potential of novel immunotherapies approach that synergistically combines radiotherapy, chemotherapy, and surgery, thereby paving the way for improved immunotherapeutic strategies against glioma and enhanced patient outcomes.http://www.sciencedirect.com/science/article/pii/S2090123224003151Glioma microenvironmentImmune cell heterogeneityTumor-initiated subtype transformationChemotherapy resistanceDetecting technologies |
| spellingShingle | Tongzheng Chen Wenbin Ma Xin Wang Qile Ye Xintong Hou Yiwei Wang Chuanlu Jiang Xiangqi Meng Ying Sun Jinquan Cai Insights of immune cell heterogeneity, tumor-initiated subtype transformation, drug resistance, treatment and detecting technologies in glioma microenvironment Journal of Advanced Research Glioma microenvironment Immune cell heterogeneity Tumor-initiated subtype transformation Chemotherapy resistance Detecting technologies |
| title | Insights of immune cell heterogeneity, tumor-initiated subtype transformation, drug resistance, treatment and detecting technologies in glioma microenvironment |
| title_full | Insights of immune cell heterogeneity, tumor-initiated subtype transformation, drug resistance, treatment and detecting technologies in glioma microenvironment |
| title_fullStr | Insights of immune cell heterogeneity, tumor-initiated subtype transformation, drug resistance, treatment and detecting technologies in glioma microenvironment |
| title_full_unstemmed | Insights of immune cell heterogeneity, tumor-initiated subtype transformation, drug resistance, treatment and detecting technologies in glioma microenvironment |
| title_short | Insights of immune cell heterogeneity, tumor-initiated subtype transformation, drug resistance, treatment and detecting technologies in glioma microenvironment |
| title_sort | insights of immune cell heterogeneity tumor initiated subtype transformation drug resistance treatment and detecting technologies in glioma microenvironment |
| topic | Glioma microenvironment Immune cell heterogeneity Tumor-initiated subtype transformation Chemotherapy resistance Detecting technologies |
| url | http://www.sciencedirect.com/science/article/pii/S2090123224003151 |
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