Optimal timing for assessing post-intensive care syndrome in clinical research: a scoping review and expert survey
Abstract Background Since the concept of post-intensive care syndrome (PICS) was proposed, numerous studies have assessed patients and their family members. However, a wide range of assessment timings has been employed across previous studies. This study aimed to clarify how assessment timings have...
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2025-08-01
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| author | Kohei Tanaka Nobuto Nakanishi Keibun Liu Kyohei Miyamoto Akira Kawauchi Masatsugu Okamura Sho Katayama Yuki Iida Yusuke Kawai Junji Hatakeyama Toru Hifumi Takeshi Unoki Daisuke Kawakami Fumimasa Amaya Kengo Obata Hidenori Sumita Tomoyuki Morisawa Norihiko Tsuboi Ryo Kozu Shunsuke Takaki Junpei Haruna Kohei Ota Yoshihisa Fujinami Nobuyuki Nosaka Kasumi Shirasaki Shigeaki Inoue Osamu Nishida Kensuke Nakamura |
| author_facet | Kohei Tanaka Nobuto Nakanishi Keibun Liu Kyohei Miyamoto Akira Kawauchi Masatsugu Okamura Sho Katayama Yuki Iida Yusuke Kawai Junji Hatakeyama Toru Hifumi Takeshi Unoki Daisuke Kawakami Fumimasa Amaya Kengo Obata Hidenori Sumita Tomoyuki Morisawa Norihiko Tsuboi Ryo Kozu Shunsuke Takaki Junpei Haruna Kohei Ota Yoshihisa Fujinami Nobuyuki Nosaka Kasumi Shirasaki Shigeaki Inoue Osamu Nishida Kensuke Nakamura |
| author_sort | Kohei Tanaka |
| collection | DOAJ |
| description | Abstract Background Since the concept of post-intensive care syndrome (PICS) was proposed, numerous studies have assessed patients and their family members. However, a wide range of assessment timings has been employed across previous studies. This study aimed to clarify how assessment timings have been implemented in existing PICS research through a scoping review, and to explore expert opinions on optimal assessment timing via an online survey. Methods We conducted a scoping review of studies assessing PICS-related outcomes, including physical, cognitive, and psychological impairments, as well as PICS in family members. Studies were retrieved from MEDLINE, CENTRAL, and CINAHL, and screened by two independent pairs of reviewers. Eligible studies were published between January 2014 and December 2022. Studies lacking a clear description of assessment timing were excluded. We analyzed the reference point used to determine assessment schedules, the assessment time points, and their frequency. Additionally, an online questionnaire was administered to 23 members of the Japanese Society of Intensive Care Medicine PICS committee and working group members to collect expert opinions on these three aspects for clinical research. Results A total of 657 studies were included. In prior studies, hospital discharge was the most commonly used reference point for determining assessment schedule (240 studies, 40%). However, ICU discharge was identified by experts as the ideal reference point (16 votes, 47%). The most frequently used assessment time points were 3 months (262, 23%), 6 months (212, 19%), and 12 months (206, 18%) post-discharge. Experts most commonly selected the period between 6 and 12 months as the optimal time point for assessment. While single assessments were most common in previous studies (337, 51%), experts considered three assessments to be ideal (12, 44%). Conclusions This study revealed notable discrepancies between the assessment timing reported in previous studies and the opinions of experts regarding optimal timing. Standardization of assessment timing in PICS research is warranted to enhance methodological consistency and comparability. |
| format | Article |
| id | doaj-art-7515595abeed44c7924b3d8fa8abf2f7 |
| institution | Kabale University |
| issn | 2052-0492 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Intensive Care |
| spelling | doaj-art-7515595abeed44c7924b3d8fa8abf2f72025-08-20T03:44:00ZengBMCJournal of Intensive Care2052-04922025-08-011311910.1186/s40560-025-00817-8Optimal timing for assessing post-intensive care syndrome in clinical research: a scoping review and expert surveyKohei Tanaka0Nobuto Nakanishi1Keibun Liu2Kyohei Miyamoto3Akira Kawauchi4Masatsugu Okamura5Sho Katayama6Yuki Iida7Yusuke Kawai8Junji Hatakeyama9Toru Hifumi10Takeshi Unoki11Daisuke Kawakami12Fumimasa Amaya13Kengo Obata14Hidenori Sumita15Tomoyuki Morisawa16Norihiko Tsuboi17Ryo Kozu18Shunsuke Takaki19Junpei Haruna20Kohei Ota21Yoshihisa Fujinami22Nobuyuki Nosaka23Kasumi Shirasaki24Shigeaki Inoue25Osamu Nishida26Kensuke Nakamura27Department of Rehabilitation Medicine, Osaka International Medical & Science CenterDivision of Disaster and Emergency Medicine, Department of Surgery Related, Kobe University Graduate School of MedicineNon-Profit Organization ICU Collaboration Network (ICON)Department of Emergency and Critical Care Medicine, Wakayama Medical UniversityDepartment of Critical Care and Emergency Medicine, Japanese Red Cross Maebashi HospitalBerlin Institute of Health Center for Regenerative Therapies (BCRT), Charité – Universitätsmedizin BerlinDepartment of Rehabilitation Medicine, Okayama University HospitalDepartment of Physical Therapy, School of Health Sciences, Aichi Shukutoku UniversityDepartment of Nursing, Fujita Health University HospitalDepartment of Emergency and Critical Care Medicine, Osaka Medical and Pharmaceutical UniversityDepartment of Emergency and Critical Care Medicine, St. Luke’s International HospitalDepartment of Acute and Critical Care Nursing, School of Nursing, Sapporo City UniversityDepartment of Intensive Care Medicine, Iizuka HospitalDepartment of Pain Management and Palliative Care Medicine, Kyoto Prefectural University of MedicineDepartment of Rehabilitation, Japanese Red Cross Okayama HospitalClinic SumitaDepartment of Rehabilitation, Kobe Rehabilitation HospitalDepartment of Critical Care and Anesthesia, National Center for Child Health and DevelopmentDepartment of Rehabilitation Medicine, Nagasaki University HospitalDepartment of Critical Care Medicine, Yokohama City University HospitalDepartment of Intensive Care Medicine, School of Medicine, Sapporo Medical UniversityDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Emergency Medicine, Kakogawa Central City HospitalDepartment of Intensive Care Medicine, Graduate School of Medical and Dental Sciences, Institute of Science TokyoDepartment of Emergency and Critical Care Medicine, St. Luke’s International HospitalDepartment of Emergency and Critical Care Medicine, Wakayama Medical UniversityDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Fujita Health UniversityDivision of Disaster and Emergency Medicine, Department of Surgery Related, Kobe University Graduate School of MedicineAbstract Background Since the concept of post-intensive care syndrome (PICS) was proposed, numerous studies have assessed patients and their family members. However, a wide range of assessment timings has been employed across previous studies. This study aimed to clarify how assessment timings have been implemented in existing PICS research through a scoping review, and to explore expert opinions on optimal assessment timing via an online survey. Methods We conducted a scoping review of studies assessing PICS-related outcomes, including physical, cognitive, and psychological impairments, as well as PICS in family members. Studies were retrieved from MEDLINE, CENTRAL, and CINAHL, and screened by two independent pairs of reviewers. Eligible studies were published between January 2014 and December 2022. Studies lacking a clear description of assessment timing were excluded. We analyzed the reference point used to determine assessment schedules, the assessment time points, and their frequency. Additionally, an online questionnaire was administered to 23 members of the Japanese Society of Intensive Care Medicine PICS committee and working group members to collect expert opinions on these three aspects for clinical research. Results A total of 657 studies were included. In prior studies, hospital discharge was the most commonly used reference point for determining assessment schedule (240 studies, 40%). However, ICU discharge was identified by experts as the ideal reference point (16 votes, 47%). The most frequently used assessment time points were 3 months (262, 23%), 6 months (212, 19%), and 12 months (206, 18%) post-discharge. Experts most commonly selected the period between 6 and 12 months as the optimal time point for assessment. While single assessments were most common in previous studies (337, 51%), experts considered three assessments to be ideal (12, 44%). Conclusions This study revealed notable discrepancies between the assessment timing reported in previous studies and the opinions of experts regarding optimal timing. Standardization of assessment timing in PICS research is warranted to enhance methodological consistency and comparability.https://doi.org/10.1186/s40560-025-00817-8Critical illnessIntensive care unitPhysical functionCognitive functionMental healthFamily |
| spellingShingle | Kohei Tanaka Nobuto Nakanishi Keibun Liu Kyohei Miyamoto Akira Kawauchi Masatsugu Okamura Sho Katayama Yuki Iida Yusuke Kawai Junji Hatakeyama Toru Hifumi Takeshi Unoki Daisuke Kawakami Fumimasa Amaya Kengo Obata Hidenori Sumita Tomoyuki Morisawa Norihiko Tsuboi Ryo Kozu Shunsuke Takaki Junpei Haruna Kohei Ota Yoshihisa Fujinami Nobuyuki Nosaka Kasumi Shirasaki Shigeaki Inoue Osamu Nishida Kensuke Nakamura Optimal timing for assessing post-intensive care syndrome in clinical research: a scoping review and expert survey Journal of Intensive Care Critical illness Intensive care unit Physical function Cognitive function Mental health Family |
| title | Optimal timing for assessing post-intensive care syndrome in clinical research: a scoping review and expert survey |
| title_full | Optimal timing for assessing post-intensive care syndrome in clinical research: a scoping review and expert survey |
| title_fullStr | Optimal timing for assessing post-intensive care syndrome in clinical research: a scoping review and expert survey |
| title_full_unstemmed | Optimal timing for assessing post-intensive care syndrome in clinical research: a scoping review and expert survey |
| title_short | Optimal timing for assessing post-intensive care syndrome in clinical research: a scoping review and expert survey |
| title_sort | optimal timing for assessing post intensive care syndrome in clinical research a scoping review and expert survey |
| topic | Critical illness Intensive care unit Physical function Cognitive function Mental health Family |
| url | https://doi.org/10.1186/s40560-025-00817-8 |
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