Biochemical Features of Alcohol-Induced Liver Disease in Native Versus Non-Native Canadians
The medical records of 37 native and 40 non-native adult Canadians with alcohol-induced liver disease were reviewed in order to determine whether a biochemical pattern of bile ductular injury (increase in serum alkaline phosphatase levels) was more common and/or severe in native versus non-native Ca...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1990-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1990/342594 |
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| Summary: | The medical records of 37 native and 40 non-native adult
Canadians with alcohol-induced liver disease were reviewed in order to determine
whether a biochemical pattern of bile ductular injury (increase in serum
alkaline phosphatase levels) was more common and/or severe in native versus
non-native Canadians. The results of this retrospective review revealed that
serum alkaline phosphatase levels were markedly elevated (at least three tunes
the upper limit of normal) in six of 37 (16%) native Canadians as compared to
three of 40 (7.5%) non-native Canadians (PÃ0.05). Moreover, the mean peak
serum alkaline phosphatase level for native Canadians was significantly higher
than for non-natives (262±188 iu/L versus 197±101 iu/L, respectively, mean ±
SD, PÃ0.05). Other liver enzyme and function tests were similar in the two
groups. The study also revealed chat the mean duration of hospital stay for native
Canadians with alcoholic hepatitis is significantly shorter than for nonnatives
(8.5±6.0 versus 12.7±1 1.2 days, respectively, PÃ0.05) and the overall duration
of hospital stay for patients with alcoholic liver injury has decreased in recent
years from 26 days (May 1984-85) to 9.3 days (May 1987-88). The results of this
study indicate that alcoholic liver disease in native Canadians is associated with
higher serum alkaline phosphatase levels than in non-native Canadians. |
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| ISSN: | 0835-7900 |