Global prevalence and dynamics of mecA and mecC genes in MRSA: Meta-meta-analysis, meta-regression, and temporal investigation
This study aimed to conduct first robust meta-meta-analysis on mecC and mecA-positive MRSA strains, determining their overall prevalence and temporal trends. It encompassed 14 meta-analyses, involving 322,269 samples from 553 index studies. MRSA strains exhibited mecA / mecC positivity ranging from...
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Elsevier
2025-07-01
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| Series: | Journal of Infection and Public Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034125001510 |
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| author | Adeiza Shuaibu Suleiman Prosun Bhattacharya Md. Aminul Islam |
| author_facet | Adeiza Shuaibu Suleiman Prosun Bhattacharya Md. Aminul Islam |
| author_sort | Adeiza Shuaibu Suleiman |
| collection | DOAJ |
| description | This study aimed to conduct first robust meta-meta-analysis on mecC and mecA-positive MRSA strains, determining their overall prevalence and temporal trends. It encompassed 14 meta-analyses, involving 322,269 samples from 553 index studies. MRSA strains exhibited mecA / mecC positivity ranging from 0.90 % to 69.98 %. Varied AMSTAR and QUOROM scores were observed. mecC-positive MRSA prevalence was 2.41 % (95 % CI: 0.72–7.78 %). Human mecA-positive MRSA had 21.77 % prevalence (95 % CI: 9.08–43.67 %), animal samples had 7.08 % prevalence (95 % CI: 3.93–12.42 %), and worldwide prevalence was 14.58 % (95 % CI: 6.61–29.14 %). Temporal trends reveal fluctuations, mecA prevalence spiked to 52.68 % in 2012 and decreased to 7.11 % in 2022. For mecC gene, the year 2015 marked a low incidence of 0.41 % (95 % CI: 0.05–3.54 %). Overall, mecA gene carriage surpassed mecC in MRSA strains, especially in humans. |
| format | Article |
| id | doaj-art-750c42a1758744cd819dc44e43b4ae47 |
| institution | DOAJ |
| issn | 1876-0341 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj-art-750c42a1758744cd819dc44e43b4ae472025-08-20T02:55:19ZengElsevierJournal of Infection and Public Health1876-03412025-07-0118710280210.1016/j.jiph.2025.102802Global prevalence and dynamics of mecA and mecC genes in MRSA: Meta-meta-analysis, meta-regression, and temporal investigationAdeiza Shuaibu Suleiman0Prosun Bhattacharya1Md. Aminul Islam2Department of Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna, Nigeria; Department of Clinical pharmacy and pharmacy practice, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria; Corresponding author at: Department of Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna, Nigeria.Department of Sustainable Development, Environmental Science and Engineering, KTH Royal Institute of Technology, Teknikringen 10B, Stockholm SE 10044, Sweden; Corresponding author.Advanced Molecular Lab, Department of Microbiology, President Abdul Hamid Medical College, Karimganj, Kishoreganj 2310, Bangladesh; COVID-19 Diagnostic lab, Department of Microbiology, Noakhali Science and Technology University, Noakhali 3814, Bangladesh; Corresponding author at: Advanced Molecular Lab, Department of Microbiology, President Abdul Hamid Medical College, Karimganj, Kishoreganj 2310, Bangladesh.This study aimed to conduct first robust meta-meta-analysis on mecC and mecA-positive MRSA strains, determining their overall prevalence and temporal trends. It encompassed 14 meta-analyses, involving 322,269 samples from 553 index studies. MRSA strains exhibited mecA / mecC positivity ranging from 0.90 % to 69.98 %. Varied AMSTAR and QUOROM scores were observed. mecC-positive MRSA prevalence was 2.41 % (95 % CI: 0.72–7.78 %). Human mecA-positive MRSA had 21.77 % prevalence (95 % CI: 9.08–43.67 %), animal samples had 7.08 % prevalence (95 % CI: 3.93–12.42 %), and worldwide prevalence was 14.58 % (95 % CI: 6.61–29.14 %). Temporal trends reveal fluctuations, mecA prevalence spiked to 52.68 % in 2012 and decreased to 7.11 % in 2022. For mecC gene, the year 2015 marked a low incidence of 0.41 % (95 % CI: 0.05–3.54 %). Overall, mecA gene carriage surpassed mecC in MRSA strains, especially in humans.http://www.sciencedirect.com/science/article/pii/S1876034125001510Antimicrobial resistanceTemporal changesMeta-analysesMRSAmecAmecC |
| spellingShingle | Adeiza Shuaibu Suleiman Prosun Bhattacharya Md. Aminul Islam Global prevalence and dynamics of mecA and mecC genes in MRSA: Meta-meta-analysis, meta-regression, and temporal investigation Journal of Infection and Public Health Antimicrobial resistance Temporal changes Meta-analyses MRSA mecA mecC |
| title | Global prevalence and dynamics of mecA and mecC genes in MRSA: Meta-meta-analysis, meta-regression, and temporal investigation |
| title_full | Global prevalence and dynamics of mecA and mecC genes in MRSA: Meta-meta-analysis, meta-regression, and temporal investigation |
| title_fullStr | Global prevalence and dynamics of mecA and mecC genes in MRSA: Meta-meta-analysis, meta-regression, and temporal investigation |
| title_full_unstemmed | Global prevalence and dynamics of mecA and mecC genes in MRSA: Meta-meta-analysis, meta-regression, and temporal investigation |
| title_short | Global prevalence and dynamics of mecA and mecC genes in MRSA: Meta-meta-analysis, meta-regression, and temporal investigation |
| title_sort | global prevalence and dynamics of meca and mecc genes in mrsa meta meta analysis meta regression and temporal investigation |
| topic | Antimicrobial resistance Temporal changes Meta-analyses MRSA mecA mecC |
| url | http://www.sciencedirect.com/science/article/pii/S1876034125001510 |
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