An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans.

An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans.

Cytotoxic T-lymphocyte associated protein 4 (CTLA4) is a negative regulator of T-cell proliferation. Polymorphisms in CTLA4 have been inconsistently associated with susceptibility to rheumatoid arthritis (RA) in populations of European ancestry but have not been examined in African Americans. The pr...

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Main Authors: James M Kelley, Laura B Hughes, Jeffrey D Faggard, Maria I Danila, Monica H Crawford, Yuanqing Edberg, Miguel A Padilla, Hemant K Tiwari, Andrew O Westfall, Graciela S Alarcón, Doyt L Conn, Beth L Jonas, Leigh F Callahan, Edwin A Smith, Richard D Brasington, David B Allison, Robert P Kimberly, Larry W Moreland, Jeffrey C Edberg, S Louis Bridges
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-03-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000424&type=printable
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