Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system
Abstract The proper functioning of the heart relies on the intricate interplay between the central nervous system and the local neuronal networks within the heart itself. While the central innervation of the heart has been extensively studied, the organization and functionality of the intracardiac n...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54830-w |
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| author | Andrea Pedroni Elanur Yilmaz Lisa Del Vecchio Prabesh Bhattarai Inés Talaya Vidal Yu-Wen E. Dai Konstantinos Koutsogiannis Caghan Kizil Konstantinos Ampatzis |
| author_facet | Andrea Pedroni Elanur Yilmaz Lisa Del Vecchio Prabesh Bhattarai Inés Talaya Vidal Yu-Wen E. Dai Konstantinos Koutsogiannis Caghan Kizil Konstantinos Ampatzis |
| author_sort | Andrea Pedroni |
| collection | DOAJ |
| description | Abstract The proper functioning of the heart relies on the intricate interplay between the central nervous system and the local neuronal networks within the heart itself. While the central innervation of the heart has been extensively studied, the organization and functionality of the intracardiac nervous system (IcNS) remain largely unexplored. Here, we present a comprehensive taxonomy of the IcNS, utilizing single-cell RNA sequencing, anatomical studies, and electrophysiological techniques. Our findings reveal a diverse array of neuronal types within the IcNS, exceeding previous expectations. We identify a subset of neurons exhibiting characteristics akin to pacemaker/rhythmogenic neurons similar to those found in Central Pattern Generator networks of the central nervous system. Our results underscore the heterogeneity within the IcNS and its key role in regulating the heart’s rhythmic functionality. The classification and characterization of the IcNS presented here serve as a valuable resource for further exploration into the mechanisms underlying heart functionality and the pathophysiology of associated cardiac disorders. |
| format | Article |
| id | doaj-art-750848b33cba4784b060844c4693a8d8 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-750848b33cba4784b060844c4693a8d82025-01-26T12:40:14ZengNature PortfolioNature Communications2041-17232024-12-0115111210.1038/s41467-024-54830-wDecoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous systemAndrea Pedroni0Elanur Yilmaz1Lisa Del Vecchio2Prabesh Bhattarai3Inés Talaya Vidal4Yu-Wen E. Dai5Konstantinos Koutsogiannis6Caghan Kizil7Konstantinos Ampatzis8Department of Neuroscience, Karolinska InstitutetTaub Institute for Research on Alzheimer’s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia UniversityDepartment of Neuroscience, Karolinska InstitutetTaub Institute for Research on Alzheimer’s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia UniversityDepartment of Neuroscience, Karolinska InstitutetDepartment of Neuroscience, Karolinska InstitutetDepartment of Neuroscience, Karolinska InstitutetTaub Institute for Research on Alzheimer’s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia UniversityDepartment of Neuroscience, Karolinska InstitutetAbstract The proper functioning of the heart relies on the intricate interplay between the central nervous system and the local neuronal networks within the heart itself. While the central innervation of the heart has been extensively studied, the organization and functionality of the intracardiac nervous system (IcNS) remain largely unexplored. Here, we present a comprehensive taxonomy of the IcNS, utilizing single-cell RNA sequencing, anatomical studies, and electrophysiological techniques. Our findings reveal a diverse array of neuronal types within the IcNS, exceeding previous expectations. We identify a subset of neurons exhibiting characteristics akin to pacemaker/rhythmogenic neurons similar to those found in Central Pattern Generator networks of the central nervous system. Our results underscore the heterogeneity within the IcNS and its key role in regulating the heart’s rhythmic functionality. The classification and characterization of the IcNS presented here serve as a valuable resource for further exploration into the mechanisms underlying heart functionality and the pathophysiology of associated cardiac disorders.https://doi.org/10.1038/s41467-024-54830-w |
| spellingShingle | Andrea Pedroni Elanur Yilmaz Lisa Del Vecchio Prabesh Bhattarai Inés Talaya Vidal Yu-Wen E. Dai Konstantinos Koutsogiannis Caghan Kizil Konstantinos Ampatzis Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system Nature Communications |
| title | Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system |
| title_full | Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system |
| title_fullStr | Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system |
| title_full_unstemmed | Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system |
| title_short | Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system |
| title_sort | decoding the molecular cellular and functional heterogeneity of zebrafish intracardiac nervous system |
| url | https://doi.org/10.1038/s41467-024-54830-w |
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