Osteopontin neutralization increases vitamin D receptors on NKT cells and ameliorates liver fibrosis by promoting their activity

Osteopontin neutralization increases vitamin D receptors on NKT cells and ameliorates liver fibrosis by promoting their activity

Introduction and AimsVitamin D has an immunomodulatory property influencing the activity of NKT cells. We aimed to study the impact of osteopontin (OPN), a key driver of fibrosis, on NKT cells’ vitamin D receptor (VDR) and activity alterations.MethodsLiver fibrosis was induced in BALB/C mice with ca...

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Bibliographic Details
Main Authors: Johnny Amer, Ahmad Salhab, Enas Hussini, Rasha Shweiki, Iman Zahran, Mohammad Far
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
Subjects:
liver fibrosis
NKT cells
OPN
vitamin D
VDR
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1484278/full
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