Local Ablative Strategies for Ductal Pancreatic Cancer (Radiofrequency Ablation, Irreversible Electroporation): A Review
Pancreatic ductal adenocarcinoma (PDAC) has still a dismal prognosis. Locally advanced pancreatic cancer (LAPC) accounts for the 40% of the new diagnoses. Current treatment options are based on chemo- and radiotherapy regimens. Local ablative techniques seem to be the future therapeutic option for s...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/4508376 |
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| author | Salvatore Paiella Roberto Salvia Marco Ramera Roberto Girelli Isabella Frigerio Alessandro Giardino Valentina Allegrini Claudio Bassi |
| author_facet | Salvatore Paiella Roberto Salvia Marco Ramera Roberto Girelli Isabella Frigerio Alessandro Giardino Valentina Allegrini Claudio Bassi |
| author_sort | Salvatore Paiella |
| collection | DOAJ |
| description | Pancreatic ductal adenocarcinoma (PDAC) has still a dismal prognosis. Locally advanced pancreatic cancer (LAPC) accounts for the 40% of the new diagnoses. Current treatment options are based on chemo- and radiotherapy regimens. Local ablative techniques seem to be the future therapeutic option for stage-III patients with PDAC. Radiofrequency Ablation (RFA) and Irreversible Electroporation (IRE) are actually the most emerging local ablative techniques used on LAPC. Initial clinical studies on the use of these techniques have already demonstrated encouraging results in terms of safety and feasibility. Unfortunately, few studies on their efficacy are currently available. Even though some reports on the overall survival are encouraging, randomized studies are still required to corroborate these findings. This study provides an up-to-date overview and a thematic summary of the current available evidence on the application of RFA and IRE on PDAC, together with a comparison of the two procedures. |
| format | Article |
| id | doaj-art-74f5195495ba4ae09e96da6cbfc2f0f9 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-74f5195495ba4ae09e96da6cbfc2f0f92025-08-20T02:06:58ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/45083764508376Local Ablative Strategies for Ductal Pancreatic Cancer (Radiofrequency Ablation, Irreversible Electroporation): A ReviewSalvatore Paiella0Roberto Salvia1Marco Ramera2Roberto Girelli3Isabella Frigerio4Alessandro Giardino5Valentina Allegrini6Claudio Bassi7Unit of General Surgery B, The Pancreas Institute, G.B. Rossi Hospital, University of Verona Hospital Trust, Verona, ItalyUnit of General Surgery B, The Pancreas Institute, G.B. Rossi Hospital, University of Verona Hospital Trust, Verona, ItalyUnit of General Surgery B, The Pancreas Institute, G.B. Rossi Hospital, University of Verona Hospital Trust, Verona, ItalyPancreatic Surgical Unit, Casa di Cura Pederzoli, Peschiera del Garda, Verona, ItalyPancreatic Surgical Unit, Casa di Cura Pederzoli, Peschiera del Garda, Verona, ItalyPancreatic Surgical Unit, Casa di Cura Pederzoli, Peschiera del Garda, Verona, ItalyUnit of General Surgery B, The Pancreas Institute, G.B. Rossi Hospital, University of Verona Hospital Trust, Verona, ItalyUnit of General Surgery B, The Pancreas Institute, G.B. Rossi Hospital, University of Verona Hospital Trust, Verona, ItalyPancreatic ductal adenocarcinoma (PDAC) has still a dismal prognosis. Locally advanced pancreatic cancer (LAPC) accounts for the 40% of the new diagnoses. Current treatment options are based on chemo- and radiotherapy regimens. Local ablative techniques seem to be the future therapeutic option for stage-III patients with PDAC. Radiofrequency Ablation (RFA) and Irreversible Electroporation (IRE) are actually the most emerging local ablative techniques used on LAPC. Initial clinical studies on the use of these techniques have already demonstrated encouraging results in terms of safety and feasibility. Unfortunately, few studies on their efficacy are currently available. Even though some reports on the overall survival are encouraging, randomized studies are still required to corroborate these findings. This study provides an up-to-date overview and a thematic summary of the current available evidence on the application of RFA and IRE on PDAC, together with a comparison of the two procedures.http://dx.doi.org/10.1155/2016/4508376 |
| spellingShingle | Salvatore Paiella Roberto Salvia Marco Ramera Roberto Girelli Isabella Frigerio Alessandro Giardino Valentina Allegrini Claudio Bassi Local Ablative Strategies for Ductal Pancreatic Cancer (Radiofrequency Ablation, Irreversible Electroporation): A Review Gastroenterology Research and Practice |
| title | Local Ablative Strategies for Ductal Pancreatic Cancer (Radiofrequency Ablation, Irreversible Electroporation): A Review |
| title_full | Local Ablative Strategies for Ductal Pancreatic Cancer (Radiofrequency Ablation, Irreversible Electroporation): A Review |
| title_fullStr | Local Ablative Strategies for Ductal Pancreatic Cancer (Radiofrequency Ablation, Irreversible Electroporation): A Review |
| title_full_unstemmed | Local Ablative Strategies for Ductal Pancreatic Cancer (Radiofrequency Ablation, Irreversible Electroporation): A Review |
| title_short | Local Ablative Strategies for Ductal Pancreatic Cancer (Radiofrequency Ablation, Irreversible Electroporation): A Review |
| title_sort | local ablative strategies for ductal pancreatic cancer radiofrequency ablation irreversible electroporation a review |
| url | http://dx.doi.org/10.1155/2016/4508376 |
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