MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts

MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts

Abstract The MYC oncoprotein regulates numerous genes involved in processes such as cell cycle control and mitochondrial and ribosomal structure and function. This requires heterodimerization with its partner, MAX, and binding to specific promoter and enhancer elements. Here, it is shown that MYC an...

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Bibliographic Details
Main Authors: Huabo Wang, Bingwei Ma, Taylor Stevens, Jessica Knapp, Jie Lu, Edward V. Prochownik
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
BRD4
chromatin
CTCF
DNA looping
enhancers
mediator
Online Access:https://doi.org/10.1002/advs.202414601
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