Complex regulation of Cav2.2 N-type Ca2+ channels by Ca2+ and G-proteins.

Complex regulation of Cav2.2 N-type Ca2+ channels by Ca2+ and G-proteins.

G-protein coupled receptors inhibit Cav2.2 N-type Ca2+ channels by a fast, voltage-dependent pathway mediated by Gαi/Gβγ and a slow, voltage-independent pathway mediated by Gαq-dependent reductions in phosphatidylinositol 4,5-bisphosphate (PIP2) or increases in arachidonic acid. Studies of these for...

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Bibliographic Details
Main Authors: Jessica R Thomas, Jinglang Sun, Juan De la Rosa Vazquez, Amy Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0314839
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