The TgAMPK-TgPFKII axis essentially regulates protein lactylation in the zoonotic parasite Toxoplasma gondii

The TgAMPK-TgPFKII axis essentially regulates protein lactylation in the zoonotic parasite Toxoplasma gondii

ABSTRACT Toxoplasma gondii infects nucleated cells of warm-blooded animals and cause zoonotic toxoplasmosis. Lysine lactylation, as a novel post-translational modification, is essential for epigenetic regulation and cellular processes, and proteomic analyses have shown that lactylated proteins are i...

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Bibliographic Details
Main Authors: Chenghuan Li, Yang Zhao, Qilong Li, Ran Chen, Ying Feng, Xiaoyu Sang, Xiangrui Li, Bang Shen, Ning Jiang, Qijun Chen
Format: Article
Language:English
Published: American Society for Microbiology 2025-03-01
Series:Microbiology Spectrum
Subjects:
Toxoplasma gondii
lactylation
TgPFKII
AMPK signaling pathway
AMPK inhibitor
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02044-24
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